OPENPediatrics

By the end of this podcast, the viewer will be able to understand the basic pathophysiology of diarrhea, describe the clinical presentation in a pediatric patient, develop a diagnosis for a child with diarrhea, and explain the management of diarrhea in children. Initial Publication Date: March 3, 2021. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

In this edition of the World Shared Practice Forum podcast, Dr. Petter Brodin, Consultant in Pediatric Immunology at the Karolinska Institute, discusses new and emerging knowledge regarding the immune response to SARS-CoV-2 infection. He also provides perspective on the immunology of the COVID-19 vaccine response, as well as the Multisystem Inflammatory Syndrome in Children (MIS-C). After this podcast, listeners will be able to: • Discuss the current understanding of COVID-19 immunology • Understand immune system responses that may influence COVID-19 disease burden and severity • Describe current theories of the immunology of the COVID-19 Multisystem Inflammatory Syndrome in Children (MIS-C) Initial publication: February 22, 2021. Speakers: Petter Brodin, MD, PhD Consultant in Pediatric Immunology, Karolinska University Hospital Professor of Pediatric Immunology, Karolinska University Jeffrey Burns, MD, MPH Chief and Shapiro Chair, Critical Care Medicine, Executive Chair, International Health Services, Director, OPENPediatrics, Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital Professor of Anesthesia, Harvard Medical School Citation: Brodin P, Zackin B, Daniel D, Burns JP. Immune determinants of COVID-19 disease presentation and severity. 2/2021. Online Podcast. OPENPediatrics. https://youtu.be/dFA68r40UMU. Resources: • Brodin P. Immune determinants of COVID-19 disease presentation and severity. Nature Medicine. 2021 Jan;27(1):28-33. • Consiglio CR, Cotugno N, Sardh F, Pou C, Amodio D, Rodriguez L, Tan Z, Zicari S, Ruggiero A, Pascucci GR, Santilli V, Brodin P. The immunology of multisystem inflammatory syndrome in children with COVID-19. Cell. 2020 Nov 12;183(4):968-81. • Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Brodin P, et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020 Oct 23;370(6515). • Rodriguez L, Brodin P. Unraveling the Immune Response in Severe COVID-19. Journal of clinical immunology. 2020 Oct;40(7):958-9. This recording is intended to be used as an educational resource for healthcare providers. It is in no way a substitute for the independent decision making and judgment of a qualified healthcare professional. It should not be used to make a diagnosis, or to overrule the advice of a qualified health care provider, nor should it be used to provide advice for emergency medical treatment. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

Listen as Dr. Gary Dhillon presents on Long QT syndrome and pearls for anesthesiologists and intensivists. Initial publication: February 9, 2021. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

Listen as Dr. Gary Dhillon discusses Brugada syndrome and pearls for the anesthesiologist and intensivist. Initial publication: February 9, 2021. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

Listen as Dr. Gary Dhillon reviews Wolff-Parkinson-White syndrome and pearls for the anesthesiologist and intensivist. Initial publication: February 9, 2021. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

In this podcast, Dr. Rick Malley, Senior Physician in Pediatrics at the Boston Children's Hospital Division of Infectious Diseases, discusses the current research on COVID-19 vaccination efforts. He discusses the safety and efficacy of the currently-approved vaccines developed by Pfizer, Moderna, and AstraZeneca, as well as some upcoming vaccines. He discusses the impact on the transmission of the virus and outlines some of the controversies and gaps of knowledge still present in research, as well as some of the challenges of making the vaccine available on a global scale. After this podcast, listeners will be able to: • Distinguish the differences between currently-approved COVID-19 vaccines • Understand the knowledge gaps and controversies in current vaccine research • Gain a broader picture of global delivery implications related to COVID-19 vaccinations Initial publication: January 22, 2021. Speakers: Rick Malley, MD Senior Physician in Pediatrics, Division of Infectious Diseases, Boston Children’s Hospital Professor of Pediatrics, Harvard Medical School Jeffrey Burns, MD, MPH Chief and Shapiro Chair, Critical Care Medicine, Executive Chair, International Health Services, Director, OPENPediatrics, Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital Professor of Anesthesia, Harvard Medical School Citation: Malley R, Zackin B, Wolbrink TA, Burns JP. Updates on COVID-19 Vaccines. 01/2021. Online Podcast. OPENPediatrics. https://soundcloud.com/openpediatrics/updates-on-covid-19-vaccines. This recording is intended to be used as an educational resource for healthcare providers. It is in no way a substitute for the independent decision making and judgment of a qualified healthcare professional. It should not be used to make a diagnosis, or to overrule the advice of a qualified health care provider, nor should it be used to provide advice for emergency medical treatment. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

Listeners will learn how this team supported and educated frontline staff about how to provide safe care of themselves, patients, and families during the COVID-19 crisis. Initial publication: January 15, 2021. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

Dr. Anjuli Sinha reviews how to perform a differential diagnosis in a hypoxic patient with congenital heart disease, and reviews a case study on how to recognize and treat shunt thrombosis. Initial Publication: January 8, 2021. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

In this module, we will discuss identification, assessment, and management of a febrile, neutropenic pediatric oncology patient. Initial publication: January 6, 2021. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

In this podcast, the viewer will learn comprehensively about urinary tract infection: how to recognize its risk factors and clinical presentation, how to describe its pathophysiology, and how to appropriately diagnose and care for affected children. Please visit: http://www.openpediatrics.orgOPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu