OPENPediatrics Immune Determinants of COVID-19 Disease Presentation and Severity by P. Brodin | OPENPediatrics
Feb 22, 2021
22:09
In this edition of the World Shared Practice Forum podcast, Dr. Petter Brodin, Consultant in Pediatric Immunology at the Karolinska Institute, discusses new and emerging knowledge regarding the immune response to SARS-CoV-2 infection. He also provides perspective on the immunology of the COVID-19 vaccine response, as well as the Multisystem Inflammatory Syndrome in Children (MIS-C).
After this podcast, listeners will be able to:
• Discuss the current understanding of COVID-19 immunology
• Understand immune system responses that may influence COVID-19 disease burden and severity
• Describe current theories of the immunology of the COVID-19 Multisystem Inflammatory Syndrome in Children (MIS-C)
Initial publication: February 22, 2021.
Speakers:
Petter Brodin, MD, PhD
Consultant in Pediatric Immunology, Karolinska University Hospital
Professor of Pediatric Immunology, Karolinska University
Jeffrey Burns, MD, MPH
Chief and Shapiro Chair, Critical Care Medicine,
Executive Chair, International Health Services,
Director, OPENPediatrics,
Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine,
Boston Children's Hospital
Professor of Anesthesia, Harvard Medical School
Citation:
Brodin P, Zackin B, Daniel D, Burns JP. Immune determinants of COVID-19 disease presentation and severity. 2/2021. Online Podcast. OPENPediatrics. https://youtu.be/dFA68r40UMU.
Resources:
• Brodin P. Immune determinants of COVID-19 disease presentation and severity. Nature Medicine. 2021 Jan;27(1):28-33.
• Consiglio CR, Cotugno N, Sardh F, Pou C, Amodio D, Rodriguez L, Tan Z, Zicari S, Ruggiero A, Pascucci GR, Santilli V, Brodin P. The immunology of multisystem inflammatory syndrome in children with COVID-19. Cell. 2020 Nov 12;183(4):968-81.
• Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Brodin P, et al. Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science. 2020 Oct 23;370(6515).
• Rodriguez L, Brodin P. Unraveling the Immune Response in Severe COVID-19. Journal of clinical immunology. 2020 Oct;40(7):958-9.
This recording is intended to be used as an educational resource for healthcare providers. It is in no way a substitute for the independent decision making and judgment of a qualified healthcare professional. It should not be used to make a diagnosis, or to overrule the advice of a qualified health care provider, nor should it be used to provide advice for emergency medical treatment.
Please visit: www.openpediatrics.org
OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.
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