OPENPediatrics

In this World Shared Practice Forum podcast, Dr. Robert Tasker discusses highlights from his first year as Editor-in-Chief of the Pediatric Critical Care Medicine Journal. Dr. Tasker shares his views on some of the most active areas of research and discussion in the field of pediatric critical care medicine in 2021, along with an in-depth look at reach and impact data for a number of the most widely read articles of the year published by PCCM. Learning Objectives -Identify areas of active investigation and discussion in the field of pediatric critical care medicine in 2021 -List prominent articles published in the Pediatric Critical Care Medicine journal published in 2021, as recommended by the Editor-in-Chief of Pediatric Critical Care Medicine -Identify some of the guiding principles of the Editor-in-Chief of Pediatric Critical Care Medicine applied in selecting articles for publication Initial publication date: February 18, 2022 Citation: Tasker R, Daniel D, Burns JP. Part 1: PCCM - Year in Review: Thoughts From the Editor-in-Chief. 2/2022. Online Podcast. OPENPediatrics. https://youtu.be/F995J0JnlZ4. Articles referenced -Tasker R. C. (2021). 2021 in Review. Pediatric critical care medicine: a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 22(12), 1009–1010. (4:07) -https://journals.lww.com/pccmjournal/pages/collectiondetails.aspx?TopicalCollectionId=25 (5:17) -Wong HR, Reeder RW, Banks R, et al. Biomarkers for Estimating Risk of Hospital Mortality and Long-Term Quality-of-Life Morbidity After Surviving Pediatric Septic Shock: A Secondary Analysis of the Life After Pediatric Sepsis Evaluation Investigation. Pediatr Crit Care Med. 2021;22(1):8-15. (11:35) -Rimensberger PC, Kneyber MCJ, Deep A, et al. Caring for Critically Ill Children With Suspected or Proven Coronavirus Disease 2019 Infection: Recommendations by the Scientific Sections' Collaborative of the European Society of Pediatric and Neonatal Intensive Care. Pediatr Crit Care Med. 2021;22(1):56-67. (9:37) -Jonat B, Gorelik M, Boneparth A, et al. Multisystem Inflammatory Syndrome in Children Associated With Coronavirus Disease 2019 in a Children's Hospital in New York City: Patient Characteristics and an Institutional Protocol for Evaluation, Management, and Follow-Up. Pediatr Crit Care Med. 2021;22(3):e178-e191. (9:58) -Tripathi S, Gist KM, Bjornstad EC, et al. Coronavirus Disease 2019-Associated PICU Admissions: A Report From the Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study Registry. Pediatr Crit Care Med. 2021;22(7):603-615. (10:08) -Woods KS, Horvat CM, Kantawala S, et al. Intracranial and Cerebral Perfusion Pressure Thresholds Associated With Inhospital Mortality Across Pediatric Neurocritical Care. Pediatr Crit Care Med. 2021;22(2):135-146. (11:58) -Mitting RB, Peshimam N, Lillie J, et al. Invasive Mechanical Ventilation for Acute Viral Bronchiolitis: Retrospective Multicenter Cohort Study. Pediatr Crit Care Med. 2021;22(3):231-240. (12:36) -Sleeper LA, Mulone M, Diallo F, et al. Stratification of Bleeding Risk Using Thromboelastography in Children on Extracorporeal Membrane Oxygenation Support. Pediatr Crit Care Med. 2021;22(3):241-250. (13:04) -Patel RV, Redivo J, Nelliot A, et al. Early Mobilization in a PICU: A Qualitative Sustainability Analysis of PICU Up!. Pediatr Crit Care Med. 2021;22(4):e233-e242. (13:32) -https://journals.lww.com/pccmjournal/pages/collectiondetails.aspx?TopicalCollectionId=27 (18:10) -Tasker RC. PCCM Narratives, Letters, and Correspondence. Pediatr Crit Care Med. 2021;22(4):426-427. (18:35) -Schober ME, Pavia AT, Bohnsack JF. Neurologic Manifestations of COVID-19 in Children: Emerging Pathophysiologic Insights. Pediatr Crit Care Med. 2021;22(7):655-661. (19:43)

Hector Wong, MD, Vice Chair of the Department of Pediatrics at Cincinnati Children’s Hospital Medical Center, passed away unexpectedly in January 2022. Dr. Wong was known as a brilliant scientist, mentor, and leader who dedicated his career to pediatric critical care research and fighting pediatric sepsis. He spent the majority of his career caring for patients and their families at Cincinnati Children’s Hospital Medical Center where he served as Director of the Pediatric Critical Care Fellowship Program until 2004 and Director of the Division of Critical Care Medicine until 2020. Dr. Wong developed the Pediatric Sepsis Biomarker Risk Model PERSEVERE which helped for early identification and treatment of sepsis. Dr. Wong spoke about the use of his Pediatric Sepsis Biomarker Risk Model PERSEVERE in sepsis clinical trials at the 2016 PICC World Congress. This updated video contains a special tribute introduction by Dr. Paul Shanley, President and CEO of Ann and Robert H. Lurie Children's Hospital of Chicago. Publication date: February 17, 2022. Initial publication date: August 11, 2017. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

Dr. John Downes was a pioneer in the fields of Anesthesiology and Critical Care Medicine who changed the lives of thousands. He will always be remembered as a devoted clinician and visionary leader. In this podcast, Dr. Robert Berg, Division Chief and Russell C. Raphaely Endowed Chair in Critical Care Medicine at Children's Hospital of Philadelphia, remarks on the career and accomplishments of Dr. Downes as an introduction to an honorary republication of the World Shared Practice presentation by Dr. Downes, previously published on May 26, 2017. In that presentation, Dr. John Downes gives his unique perspective on the growth of the modern Intensive Care Unit from its origins while recounting some of his own experiences as a pediatric intensivist. Upon viewing this presentation, participants will be able to: - Identify the impacts made on Modern Medicine by the discovery of anesthesia, expansion of nursing care, and application of asepsis - Recognize influential medical professionals who advocated for the rights of sick children in the early 20th century - Reference significant historical milestones in the development of respiratory therapies and best practices in the Intensive Care Unit Publication date: January 24, 2022. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

This podcast will provide information about the impact of immunizations on disease incidence, how immunizations work, and the recommended immunization schedule for children. Learning Objectives: - Understand the impact of childhood immunizations on disease incidence and morbidity - Describe how immunizations work - Explain which immunizations are given at each well-child visit. - Recognize special circumstances that affect the immunization schedule Initial Publication: January 5, 2022 Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

In part 2 of this World Shared Practice Forum podcast, Dr. Paul Offit, Professor of Pediatrics in the Division of Infectious Disease and the Director of the Vaccine Education Center at The Children's Hospital of Philadelphia, updates listeners on the latest data in the field of COVID vaccination. He summarizes results from Pfizer’s phase 3 vaccine trial involving 5- to 11-year olds, and discusses the considerations behind the recommendation of a third "booster" vaccine dose for all eligible age groups. He also explains what is known about COVID virus variants, including Omicron. Learning Objectives: After listening to this podcast, learners will be able to: -Describe the basic structure and results of the Pfizer COVID vaccine trial involving five- to eleven-year-old children -Discuss the potential benefits of a third "booster" dose of COVID vaccine for different patient populations -Describe the risks of myocarditis and other inflammatory syndromes associated with COVID infection, and possibly with COVID vaccines -Compare the clinical characteristics of the emerging Omicron variant to earlier variants of the SARS-CoV-2 virus Articles referenced: • Offit PA. You Bet Your Life: From Blood Transfusions to Mass Vaccination, the Long and Risky History of Medical Innovation. 1st ed. Basic Books; 2021. (00:50) • Walter EB, Talaat KR, Sabharwal C, et al. Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age [published online ahead of print, 2021 Nov 9]. N Engl J Med. 2021;NEJMoa2116298. doi:10.1056/NEJMoa2116298 (2:52) • Daniels CJ, Rajpal S, Greenshields JT, et al. Prevalence of Clinical and Subclinical Myocarditis in Competitive Athletes With Recent SARS-CoV-2 Infection: Results From the Big Ten COVID-19 Cardiac Registry. JAMA Cardiol. 2021;6(9):1078-1087. doi:10.1001/jamacardio.2021.2065 (11:30) Intial publication: December 14, 2021 Citation: Offit PA, Daniel D, Burns JP. Pediatric Vaccine for COVID-19: Update on COVID-19 vaccine for 5-11 year olds, booster doses, and the Omicron variant. 12/2021. Online Podcast. OPENPediatrics. Offit PA, Daniel D, Burns JP. Pediatric Vaccine for COVID-19 Part 2: Update on the Vaccine for 5-11-yrs, Boosters, and Omicron. 12/2021. Online Podcast. OPENPediatrics. https://youtu.be/BcktvXuIsyI. Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

In this podcast, Dr. Armstrong reviews how to identify and treat a leaking or dislodged gastrostomy tube (G-tube), which are two of the most common G-tube complications. Initial publication date: December 7, 2021 Please visit: www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

In this podcast, Dr. Lindsey Armstrong reviews the different types of gastrostomy tubes (G-tubes) and discusses the clinical situations in which each would be used. Initial publication date: December 2, 2021 Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

In this World Shared Practice Forum podcast, Dr. Martin Kneyber, Chief of the Division of Paediatric Critical Care Medicine at the Beatrix Children’s Hospital, provides an insightful overview of the current state of thinking regarding the concepts of mechanical power and driving pressure in adult and pediatric mechanical ventilation. He provides his perspective on current evidence-based best practices for lung protective ventilation in pediatric ARDS, and highlights important areas for ongoing and future research. Learning Objectives: -Review the concepts and interrelations between mechanical power, driving pressure, plateau pressure -Understand the state of evidence linking driving pressure to outcomes in adult and pediatric patients receiving mechanical ventilation -Describe current evidence-based best clinical practices in adjusting mechanical ventilation in pediatric patients with acute respiratory distress syndrome (ARDS) Articles referenced: • Kneyber MC. Driving Pressure and Mechanical Power: The Return of Physiology in Pediatric Mechanical Ventilation. Pediatric Critical Care Medicine. 2021 Oct 1;22(10):927-9. (00:57) • Díaz, Franco, González-Dambrauskas, Sebastián, Cristiani, Federico, Casanova, Daniel R., Cruces, Pablo, Driving Pressure and Normalized Energy Transmission Calculations in Mechanically Ventilated Children Without Lung Disease and Pediatric Acute Respiratory Distress Syndrome, Pediatric Critical Care Medicine: 2021 Oct 1;22(10):870-8 (2:01) • Amato MB, Meade MO, Slutsky AS, et al. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med. 2015;372(8):747-755. (5:58) • van Schelven P, Koopman AA, Burgerhof JGM, Markhorst DG, Blokpoel RGT, Kneyber MCJ. Driving Pressure Is Associated With Outcome in Pediatric Acute Respiratory Failure [published online ahead of print, 2021 Oct 20]. Pediatr Crit Care Med. 2021;10.1097/PCC.0000000000002848.(8:17) Publication Date: November 22, 2021. Citation: Kneyber M, Daniel D, Burns JP. Driving Pressure: The return of physiology in pediatric mechanical ventilation. 11/2021. Online Podcast. OPENPediatrics. https://soundcloud.com/openpediatrics/driving-pressure-the-return-of-physiology-in-pediatric-mechanical-ventilation-dr-martin-kneyber. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching a full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu

Dr. Kate Douglas, expert in working with interpreters in the clinical setting, shares best practices for effectively working with interpreters, including the importance of using professional medical interpreters, different methods of interpretation, and strategies for clear communication and understanding with interpreters during medical consultations.

In this World Shared Practice Forum podcast, Dr. Paul Offit, Director of the Vaccine Education Center, co-inventor of the rotavirus vaccine, member of the FDA Vaccine Advisory Committee, and attending physician in the Division of Infectious Diseases at Children’s Hospital of Philadelphia, shares his perspective on issues relating to COVID-19 vaccination in children. He provides historical perspective on prior pediatric vaccine development efforts, and shares his insights into the appraisal of scientific evidence and decision-making processes that are involved in federal approval of the COVID-19 vaccines.   After this podcast, listeners will be able to: -Understand the challenges behind COVID-19 vaccination development for children from a historical perspective -Describe the available evidence relating to antibody-dependent enhancement and vaccine-associated enhancement of disease with the COVID-19 vaccines -Describe the considerations involved in federally approving COVID-19 vaccines for children Initial publication date: October 22, 2021 Citation: Offit P, Daniel D, Burns JP. Pediatric Vaccine for COVID-19 Part 1. 10/2021. Online Podcast. OPENPediatrics. https://soundcloud.com/openpediatrics/pediatric-vaccine-for-covid-19-part-1-by-dr-paul-offit-for-openpediatrics. Please visit: http://www.openpediatrics.org OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children’s Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user. For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu