Neurology® Podcast

Dr. Patricia Pozo-Rosich, a leading expert in headache medicine from Valdebron University Hospital, shares insights into groundbreaking advancements in migraine treatment. She emphasizes the importance of early intervention for better patient outcomes and discusses significant studies from 2024 that unveil new therapeutic targets. The conversation also highlights the transformative role of patient feedback and the integration of AI in personalized headache management, while expressing hope for forthcoming treatment innovations.

Dr. Wallace J. Brownlee, a renowned neurologist specializing in multiple sclerosis from Queen Square MS Centre, dives into the evolving landscape of MS diagnosis. He discusses the diminishing focus on dissemination in time (DIT) when high dissemination in space (DIS) criteria are met. The conversation also covers advanced diagnostic techniques like MRI and cerebrospinal fluid analysis. Brownlee outlines the significance of detecting lesions and emphasizes the role of optic neuritis in refining current guidelines for diagnosing relapsing remitting MS.

Dr. Seemant Chaturvedi, a stroke neurology expert from the University of Maryland, shares cutting-edge insights from the International Stroke Conference. He discusses important advancements in stroke treatments, including the role of endovascular therapy and findings from trials such as ESCAPE-MeVO and PRESTIAGE-AF. Chaturvedi also explores the complexities of anticoagulant use post-brain hemorrhage and innovative approaches like transcranial direct current stimulation for recovery. His expert insights emphasize the ongoing evolution of stroke care and research.

Dr. Anne Oaklander, an Associate Professor of Neurology at Harvard, discusses the connection between long COVID and small fiber neuropathy, shedding light on significant diagnostic challenges. She also shares effective management strategies. Dr. Carmel Armon from Loma Linda University tackles the efficacy of epidural steroid injections for spinal issues, presenting mixed results. The conversation highlights the importance of personalized treatment plans and improved research for managing neuropathic pain and conditions like diabetic neuropathy.

Dr. Lorraine Kalia, an associate professor of neurology at the University of Toronto and senior scientist at the Krembil Brain Institute, dives into the intriguing world of GLP-1 receptor agonists as potential treatments for neurodegenerative diseases. She shares insights on the mixed results from recent clinical trials, notably with exenatide, and discusses the promising preclinical benefits such as reduced inflammation. Kalia emphasizes the challenges of translating lab findings to human applications, while pointing to the potential for these therapies in conditions like Parkinson's and Alzheimer's.

Dr. Aaron Shoskes, a researcher from the University of Utah, discusses the alarming rise of ischemic strokes in young adults. He highlights the growing influence of hypertension and obesity as traditional risk factors. The talk delves into healthcare disparities, particularly among young Black stroke patients. Shoskes emphasizes the need for rethinking stroke management strategies and how lifestyle factors contribute to increasing polymorbidity. Community outreach and innovative technology are suggested as crucial tools in combating this urgent public health issue.

Dr. Carmel Armon, a neurologist at Loma Linda University, discusses the effectiveness of epidural steroid injections in treating cervical and lumbar radicular pain. She emphasizes the contrast between anecdotal evidence and clinical studies, revealing the injections provide limited long-term relief, with modest short-term pain reduction. The conversation highlights the complexities of pain management and the need for further research to clarify treatment outcomes and set realistic patient expectations.

Dr. Gregg Day, a renowned neurologist at Mayo Clinic and co-author of a key paper on brain health, shares insightful strategies for enhancing patients' cognitive well-being. He discusses the innovative Brain Health Initiative and its mnemonic tool 'Safest Brains' to educate clinicians on optimal neurological function. The conversation also touches on the impact of social determinants on neurologic care and the SACO Scholars Program, which fosters brain health education and leadership. This dialogue emphasizes the vital role neurologists play in advocating for comprehensive brain health.

Dr. Shuvro Roy talks with Dr. Giovanna S. Manzano about the management of neurosarcoidosis, highlighting the challenges in diagnosis, treatment approaches, and the importance of collaboration among specialists. Read the related article in Neurology: Clinical Practice. Disclosures can be found at Neurology.org.

Dean Ornish, founder of the Preventive Medicine Research Institute, shares insights on transformative lifestyle changes for improving cognition in early dementia. He discusses groundbreaking research showing significant cognitive enhancements through non-drug interventions. The importance of social support and cognitive engagement is emphasized, highlighting how meaningful conversations can uplift those affected by dementia. Ornish also explores the success of remote clinical trials during the pandemic and the potential for Medicare to cover these life-changing strategies.