
Infinite Loops
Every Thursday, join Jim O'Shaughnessy and his favorite people as they arm you with the tools & fresh perspectives required to upgrade your HumanOS and thrive in our messy, probabilistic world.
Visit our Substack at newsletter.osv.llc for full transcripts, highlights, weekly doses of timeless wisdom, and a bounty of other goodies designed to make you go, "Hmm that’s interesting!"
Latest episodes

May 9, 2024 • 1h 5min
Grant Mitchell — The Potential of AI Drug Repurposing
Grant Mitchell, entrepreneur in health and AI, discusses AI in drug repurposing, the Organizational Problem in Pharma, Biomedical Knowledge Graphs, risks in AI-driven drug discovery, neglected knowledge, and the role of translators. He also talks about innovative drug repurposing, the potential of AI in patient relief, constructing biomedical knowledge graphs, and revolutionizing drug repurposing in healthcare.

May 2, 2024 • 1h 14min
Jimmy Soni — The Courage of Creative Risk (EP.214)
Author and friend-of-the-show Jimmy Soni discusses the future of publishing, the changing world of book marketing, the courage of creative risk, and emphasizes the importance of trying new things. Topics include traditional publishing stasis, talent spotting, self-publishing challenges, and the value of collaboration in publishing.

4 snips
Apr 25, 2024 • 1h 16min
Arjun Khemani — The Hunt for Better Problems (EP. 213)
Guest Arjun Khemani, a 17-year-old dropout and podcaster, discusses voluntary education, the moral case for selfishness, and the pessimism of ultimacy in a thought-provoking podcast conversation.

Apr 18, 2024 • 1h 4min
Eddy Elfenbein — On Crossing Wall Street (EP. 212)
Eddy Elfenbein, a finance blogger with over 25 years of experience, discusses his famous Buy List, ETF journey, investing philosophy, and more. Topics include sustainable edge in markets, debating academic finance, unpacking ETFs, and the future of market intelligence.

Apr 10, 2024 • 1h 21min
Anna Gát — We Digress (EP. 211)
Returning guest-of-the-show Anna Gát discusses various topics such as navigating loss, facilitating better conversations, the humanness of Casablanca, the personality of language, and cities as ideas. The conversation also touches on authenticity, the influence of language on personality, problem-solving through language diversity, and shaping the world's perspective.

8 snips
Apr 4, 2024 • 1h 48min
Visakan Veerasamy — Expanding Our Possibility-Space (EP. 210)
Visakan Veerasamy, known writer and thinker, discusses creativity, curiosity, reality tunnels, and the power of noticing in a wide-ranging conversation. Topics include the impact of language, tools, cognitive diversity, and embracing optimism to expand our possibility space.

35 snips
Mar 28, 2024 • 1h 39min
Brendan McCord — AI and the Philosophy of Technology
Brendan McCord, Founder of Cosmos Institute, explores AI & philosophy, AI schools of thought, existential risks, adaptive systems, & the philosophy-to-code pipeline. Discusses open-source tech, US-China situation, automation vs. augmentation, Russian realism, and cinematic visions of the future. Delve into the importance of understanding unintended consequences in complex systems and the intersection of science fiction and Russian realism in literature.

64 snips
Mar 21, 2024 • 1h 26min
Alex Komoroske — Complex Adaptivity All The Way Down (EP. 208)
Alex Komoroske discusses topics like escaping busyness, heroism, different types of magic, paradigm shifts, uncertainty, compression, and more in this fascinating podcast conversation.

46 snips
Mar 14, 2024 • 1h 27min
Cedric Chin — Accelerating Business Expertise (EP. 207)
Exploring business expertise with Cedric Chin, diving into naturalistic decision making, accelerating expertise through trial & error, staying open-minded, and the power of reading protocols. Discussing cognitive flexibility, human mimicry in tech adoption, engaging podcast dialogues, and accelerating expertise through wisdom and learning.

27 snips
Mar 7, 2024 • 1h 27min
Devon Eriksen — Theft of Fire (EP. 206)
A conversation covering themes like resource constraints, alien technology in fiction, editing processes, patronage in the digital era, and the evolving nature of money and value perception. They also discuss how writers can embrace unconventional styles, inspire hope through storytelling, and engage with readers for inspiration.