
Infinite Loops
Every Thursday, join Jim O'Shaughnessy and his favorite people as they arm you with the tools & fresh perspectives required to upgrade your HumanOS and thrive in our messy, probabilistic world.
Visit our Substack at newsletter.osv.llc for full transcripts, highlights, weekly doses of timeless wisdom, and a bounty of other goodies designed to make you go, "Hmm that’s interesting!"
Latest episodes

Jul 4, 2024 • 1h 15min
Noor Siddiqui — A Thiel Fellow’s Guide to Having Healthy Babies (EP.223)
Noor Siddiqui, founder of Orchid, discusses the culture of San Francisco, embryo screening for IVF, genetic predisposition to disease, and the importance of making reproduction safe. She shares insights on advancing technology, predicting the field's future, and the benefits of genetic testing for families outside of IVF.

8 snips
Jun 27, 2024 • 1h 20min
The Fourth Way - Mastering The Self (EP.222)
Dive into the philosophy of the Fourth Way for self-improvement and spiritual growth. Explore the four ways of being, befriending your centers, and the keys to the universe. Uncover the importance of harmonious inner development and achieving a higher state of consciousness. Connect with mystical teachings, laws of three and seven, and the journey to objective consciousness.

Jun 20, 2024 • 1h 22min
Mona Sobhani — A Neuroscientist’s Journey From Materialism to Beyond (EP.221)
Cognitive neuroscientist Mona Sobhani shares her journey from materialism to spirituality, discussing psi-phenomena research, quantum science's impact on consciousness, transcendent technology, psychedelics, and bringing humanity back into science.

8 snips
Jun 13, 2024 • 1h 35min
Ellen Fishbein — Make Art, Not Noise (EP. 220)
Ellen Fishbein, a writing coach and author, discusses traditional publishing disrespecting intelligent readers, advice for aspiring authors, insights from Shakespeare's sonnets, the impact of Herman Hesse's works, using AI in book writing, changing role of agents, and innovating in the publishing industry.

Jun 6, 2024 • 1h 7min
John A. Paulos — Avoiding Innumeracy (EP. 219)
John A. Paulos, Professor, Mathematician, and Writer, discusses math education, puzzles, cognitive biases, innumeracy, randomness ignorance, anchoring bias, Monty Hall problem, ideal math courses, nudging, and more. Topics include practical math teaching methods, misconceptions in statistics, strategies for confidence intervals, critical thinking through math, nudging in behavioral economics, and math in financial disasters.

May 30, 2024 • 1h 16min
Chris Wilcha — Flipside (EP.218)
Award-winning documentary filmmaker Chris Wilcha discusses his latest film 'Flipside,' exploring creative failure, abandoned projects, and rekindled passion. He shares stories of reviving a record store, encountering Ira Glass's creative rebirth, and uncovering unique connections in the music world. The podcast delves into the challenges of balancing artistic aspirations with commercial realities in the filmmaking industry, reflecting on the nostalgia of a beloved record store and discussing the evolving landscape of documentary filmmaking.

6 snips
May 23, 2024 • 1h 41min
Bridget Phetasy — Comedy is Dead, Long Live Comedy (EP.217)
Entrepreneur, writer, and comedian Bridget Phetasy discusses the state of comedy in America, comedic dissidence, the role of humor as a weapon, luxury beliefs, and the societal utility of comedy in a fragmented cultural landscape.

May 16, 2024 • 1h 9min
Porter Braswell — Building the Future of Leadership (EP.216)
Porter Braswell, CEO of 2045 Studio, discusses empowering professionals of color, building trust in communities, lessons from Magic Johnson's mentorship, and the importance of human capital. He shares insights on networking, partnerships, and the value of inclusive spaces in fostering leadership impact.

May 9, 2024 • 1h 5min
Grant Mitchell — The Potential of AI Drug Repurposing
Grant Mitchell, entrepreneur in health and AI, discusses AI in drug repurposing, the Organizational Problem in Pharma, Biomedical Knowledge Graphs, risks in AI-driven drug discovery, neglected knowledge, and the role of translators. He also talks about innovative drug repurposing, the potential of AI in patient relief, constructing biomedical knowledge graphs, and revolutionizing drug repurposing in healthcare.

May 2, 2024 • 1h 14min
Jimmy Soni — The Courage of Creative Risk (EP.214)
Author and friend-of-the-show Jimmy Soni discusses the future of publishing, the changing world of book marketing, the courage of creative risk, and emphasizes the importance of trying new things. Topics include traditional publishing stasis, talent spotting, self-publishing challenges, and the value of collaboration in publishing.