Two Onc Docs

Discover the fascinating world of sickle cell anemia, diving into its molecular intricacies and genetic mutations. Explore different genotypes, including homozygous sickle cell disease and sickle beta thalassemia, and their associated complications. Understand the vital differences between sickle cell trait and disease, along with the health risks involved. Delve into transfusion strategies and the critical vaccines necessary for patients. Lastly, learn about the serious complications of sickle cell disease and the treatment approaches that can improve outcomes.

Explore key topics in gastric adenocarcinoma such as risk factors, diagnostic work-up, staging, and treatment options for both local and metastatic disease. Delve into HER2 and PDL1 testing, T&M staging, and treatment strategies for early-stage gastric cancer. Learn about treatment approaches for local regional disease, including the benefits of perioperative chemotherapy. Discover advanced treatment options for metastatic gastric cancer, including targeted therapies and immunotherapy tailored to individual markers and stage.

Dive into the revolutionary world of CAR-T cell immunotherapy, where T lymphocytes are genetically modified to fight cancer. Discover the intricate processes from white blood cell collection to infusion and the approved therapies for blood cancers. Important discussions highlight supportive care measures and avoidance of steroids during treatment. Unpack the key toxicities associated with this therapy, including cytokine release syndrome and neurotoxicity, ensuring prompt medical response is crucial for patient safety.

This week’s episode will be focusing on alpha thalassemia. We will go over details on the pathophysiology, symptoms, diagnosis and treatment of alpha thalassemia variants.

Learn about the staging and treatment options for both locoregional and advanced Hepatocellular Carcinoma. Discussions include the Child-Pugh score importance, screening serotic patients with ultrasound, key treatments for early-stage HCC, and advancements in systemic therapies for advanced HCC.

Exploring the role of HPV in head and neck cancers, the importance of knowing the anatomy for diagnosis and treatment, and various treatment approaches including chemotherapy regimens, radiation toxicities, and adjuvant therapy options.

Explore the intricacies of beta thalassemia, from its genetic origins to the differing impacts of its minor, intermedia, and major forms. Discover how hemoglobin composition plays a crucial role in diagnosis and treatment. Learn about the critical complications associated with severe cases and the importance of transfusions. The discussion even touches on the challenges of iron overload and examines rare variants of the condition, offering a comprehensive look at this fascinating topic.

Exploring diagnosis, treatment, and prognostic factors of Acute Lymphoblastic Leukemia, including cytogenetics, molecular markers, targeted therapies, and toxicities. Emphasis on differentiating between B-cell & T-cell types, advanced treatment options like CAR-T therapies, and key takeaways for effective management.

Explore the diagnosis, mutations, and treatment options for gastrointestinal stromal tumors (GIST) in this episode. Learn about the effectiveness of tyrosine kinase inhibitors, medication use in high-risk patients, and the role of adjuvant matinev in surgery and therapy selection for GIST.

Explore the best study plans and techniques used by fellows in hematology/oncology for board exams. Discover personalized strategies and resources tailored to individual learning styles. Delve into essential video resources and question banks, with a spotlight on the ASH review series and hemonquestions.com for detailed explanations. Learn effective strategies that emphasize consistency, flexibility, and high-yield topics, ensuring success in real-world oncology scenarios.