

Two Onc Docs
Sam and Karine
This is Sam and Karine, and we are Two Onc Docs! We both graduated from our Heme/Onc fellowships in 2021 and became board certified in both Hematology and Oncology. Our mission with Two Onc Docs is to create short board review episodes that you can listen to on your drive to work, while you make your morning coffee, or between pages on call. This is intended to be a supplement to other established board studying resources for busy trainees. *This podcast is intended to be an educational resource for health care providers.*
Episodes
Mentioned books

Oct 31, 2022 • 11min
Porphyria
Dive into the fascinating world of porphyrias, where medical conditions sparked vampire myths! Discover the symptoms of these metabolic disorders, from photosensitivity to neurological issues. Learn about the critical diagnostic methods for acute porphyrias, including urine tests for porphyrin precursors. Explore porphyria cutanea tarda and its links to iron overload and hepatitis C. With insights on treatment strategies, this discussion equips listeners with essential knowledge for understanding and managing these intriguing conditions.

Oct 24, 2022 • 15min
Chronic Myelogenous Leukemia
This week’s episode will be focusing on Chronic Myeloid Leukemia or CML for health care providers. We will go over all the important details on the genetics of CML, diagnosis and treatment algorithms.

Oct 17, 2022 • 11min
Metastatic Breast Cancer
Explore systemic therapy guidelines for metastatic breast cancer, CDK4-6 inhibitors toxicities, second-line treatments, HER2 positive treatment options, triple negative strategies, and emerging research in the field.

Oct 10, 2022 • 16min
Localized Breast Cancer
Dive into treatment options for localized breast cancer, from radiation to systemic therapies. Explore criteria for radiation post-mastectomy and personalized systemic therapy choices. Learn about chemotherapy regimens based on receptor status and side effects of treatments. Discover tailored treatment strategies based on tumor features, receptor status, and patient preferences, including neoadjuvant chemotherapy for inflammatory breast cancer.

Oct 3, 2022 • 16min
Breast Cancer Screening, Prevention & Intro
Breast Cancer Awareness Month is here! Learn about genetic and non-genetic risk factors for breast cancer, the importance of breast screenings, differences between DCIS and LCIS, treatment options like mastectomy and lumpectomy, side effects of hormone therapy, and surgical options for invasive breast cancer.

Sep 26, 2022 • 11min
Immune Thrombocytopenia
Dive into the world of Immune Thrombocytopenia (ITP) as the hosts explore its causes and idiopathic cases. Uncover the prevalence of this acquired condition and the importance of accurate diagnosis with low platelet counts. Learn about comprehensive management strategies including conservative treatments for kids and intensive options for adults. Key insights on first-line therapies like steroids and IVIG are also discussed, alongside the significance of timely management during bleeding episodes.

Sep 19, 2022 • 12min
Diffuse Large B-Cell Lymphoma
This podcast focuses on diffuse large B-cell lymphoma (DLBCL), covering topics such as diagnostic classification, subtypes and molecular markers, necessary tests and evaluations, staging and treatment options, and different treatment regimens for refractory DLBCL. It emphasizes the importance of excisional lymph node biopsy for accurate diagnosis, highlights prognostic factors and high-risk patient considerations, and discusses the use of R-CHOP chemotherapy, radiation, and CAR T therapy. The recommended follow-up protocol for cured patients is also covered.

Sep 12, 2022 • 14min
Metastatic Non-Small Cell Lung Cancer
Exploring the evolving treatment options for metastatic non-small cell lung cancer, including traditional chemotherapy, immunotherapy, and targeted agents. Discussing the significance of targeted medications like EGFR, ALK, and ROS1 inhibitors. Emphasizing the importance of genetic mutation-based sequencing and tailored drug regimens based on PDL1 status.

Sep 6, 2022 • 15min
Localized Non-Small Cell Lung Cancer
This podcast delves into the complexities of localized non-small cell lung cancer, covering staging criteria, treatment options, including surgery, chemo, radiation, and immunotherapy. The discussion also highlights the impact of the PACIFIC trial on treatment standards and explores emerging therapies like egf targeting and immunotherapy.

Aug 29, 2022 • 12min
Uterine Cancer
Important details on risk factors, diagnosis, staging, and treatment options for uterine cancer, including less common subtypes. Risk factors include obesity and hormone replacement therapy. Treatment options include surgery, hormone therapy, radiation, and chemotherapy. Uterine sarcomas have different treatment regimens, with the addition of trastuzumab for HER2 positive tumors.