
Two Onc Docs
This is Sam and Karine, and we are Two Onc Docs! We both graduated from our Heme/Onc fellowships in 2021 and became board certified in both Hematology and Oncology. Our mission with Two Onc Docs is to create short board review episodes that you can listen to on your drive to work, while you make your morning coffee, or between pages on call. This is intended to be a supplement to other established board studying resources for busy trainees. *This podcast is intended to be an educational resource for health care providers.*
Latest episodes

Jul 11, 2022 • 13min
Metastatic Prostate Cancer
The podcast discusses the treatment options for castrate sensitive and resistant prostate cancer, including oral anti-androgen medications, docetaxel chemotherapy, radium-223, and cabazitaxel. It also explores the importance of understanding drugs and genetic testing, and discusses second-line treatments such as chemo with Kepazzi-Taxel and immunotherapy with Pembrolycumab. Additionally, it covers monitoring strategies using PSA levels and imaging, treatment options for small cell prostate cancer, castrate resistance, and genetic testing for stage four patients.

Jul 5, 2022 • 13min
Localized Prostate Cancer
Learn about localized prostate cancer, including diagnostic work-up, staging, and treatment. Understand the role of bone scans in staging and the treatment options available. Discover the management of localized prostate cancer and the importance of post-treatment surveillance. Explore the basics of staging, treatment options, and monitoring PSA doubling time during surveillance.

Jun 27, 2022 • 13min
Aplastic Anemia
This podcast explores the causes, diagnostic work-up, and treatment options for aplastic anemia. It discusses pathophysiology, presentation, and treatment options, as well as alternative treatments when initial therapies fail. The prevalence of PNH clones in aplastic anemia patients and treatment options for symptomatic patients are also discussed.

Jun 20, 2022 • 13min
Small Cell Lung Cancer
This podcast discusses small cell lung cancer, including risk factors, diagnosis, staging, and treatment options. They emphasize early detection and the limitations of treatment for relapsed disease. They explore the characteristics, pathology, and symptoms of small cell lung cancer. Starting chemotherapy immediately after diagnosis is crucial and they discuss staging imaging techniques. Treatment approaches for both limited and extensive stage small cell lung cancer are covered, including surgery, radiation, chemotherapy, and immunotherapy.

Jun 13, 2022 • 11min
Myelodysplastic Syndrome (MDS)
Today’s episode is focusing on what you need to know regarding myelodysplastic syndrome (MDS) - diagnosis, risk stratification and treatment options for low risk as well as high risk MDS.

Jun 6, 2022 • 11min
Anal Cancer
Topics discussed in this episode include rising cases of anal squamous cell carcinoma in the US, risk factors like HPV infection and smoking, diagnostic workup and staging of anal cancer, treatment regimens for different stages, alternative treatment options and surveillance protocol, and the role of immunotherapy in anal cancer treatment.

May 30, 2022 • 13min
Melanoma
This podcast discusses risk factors, diagnostic work-up, staging, and treatment options for melanoma. It covers excision margins, surgical management, and adjuvant therapy. The episode also explores staging criteria for metastatic melanoma, treatment options, side effects, and monitoring. Additionally, it mentions BRF and MEK inhibitors for metastatic melanoma, rare subtypes of melanoma, and key points for the boards.

May 23, 2022 • 14min
Thrombotic Thrombocytopenic Purpura (TTP)
Exploring Thrombotic Thrombocytopenic Purpura (TTP) including clinical characteristics, diagnosis, and causes. Discussions on the golden standard lab test, risk stratification, and treatment strategies for TTP and Hemolytic Uremic Syndrome (HUS).

May 16, 2022 • 16min
Kidney Cancer
A podcast on kidney cancer, covering risk factors, genetic conditions, staging, biopsy results, treatment options, clinical trials, restratification of metastatic RCC, cider reductive nephrectomy, treatment options for intermediate/poor risk RCC, double immunotherapy combo, epinevo vs. IOTKI, and veg FTKI side effects.

May 9, 2022 • 15min
Acute Myeloid Leukemia (AML)
This podcast episode discusses AML, including diagnosis, risk stratification, molecular testing, and treatment options. It also covers the importance of chemotherapy history, diagnostic criteria, and response assessment. Allogeneic stem cell transplant is discussed as a consideration for certain AML patients.