Two Onc Docs

This podcast discusses the treatment options and sequencing for metastatic colon cancer, including chemotherapy backbones and regional preferences. It also covers the toxicities of full fox and full theory regimens, biomarker testing and targeted therapies, later lines of treatment and oligometastatic disease, and key points in treating metastatic colon cancer.

Learn about the stages of colon cancer, risk factors and syndromes associated with the disease. Explore the staging, treatment, and comparison of different chemotherapy options for high-risk stage 2 and stage 3 patients. Discover the results of a trial comparing three months versus six months of chemotherapy in adjuvant therapy for colon cancer.

This podcast explores immune checkpoint inhibitors and how they enhance the body's ability to fight cancer. It discusses the success of immunotherapy in treating metastatic melanoma and the occurrence of pseudo progression. The podcast also covers the management of immune-related adverse events and highlights the potential life-threatening side effects of immune checkpoint inhibitors.

Pathology, presentation, diagnostics, staging, and treatment of bladder cancer. Workup process, treatment approaches, eligibility criteria for cisplatin treatment, bladder removal or preservation. Treatment options for metastatic bladder cancer, chemotherapy, immunotherapy, newer agents. Subtypes of urethhelial carcinoma, surgery for in situ cancer, upfront surgery for upper track carcinoma. Differentiating non-muscle invasive and muscle invasive bladder cancer, treatment options for metastatic urethhelial cancer.

Today's episode focuses on acute promyelocytic leukemia (APL) including chromosomal translocation, presentation, diagnosis, risk stratification, treatment, and differentiation syndrome. The importance of aggressive treatment for complications, high cure rate with Atra and ATO, and categorization of APL into risk categories are discussed. Dosing, monitoring, and potential risks of Atra and ATO treatment are also highlighted.

Welcome to Two Onc Docs! We are Sam and Karine, two recent Heme/Onc fellowship grads, and board certified oncologists and hematologists. This episode covers how we studied for the boards, skip ahead if you want board review content.