Two Onc Docs Gastric Cancer
9 snips
Mar 6, 2023 Explore key topics in gastric adenocarcinoma such as risk factors, diagnostic work-up, staging, and treatment options for both local and metastatic disease. Delve into HER2 and PDL1 testing, T&M staging, and treatment strategies for early-stage gastric cancer. Learn about treatment approaches for local regional disease, including the benefits of perioperative chemotherapy. Discover advanced treatment options for metastatic gastric cancer, including targeted therapies and immunotherapy tailored to individual markers and stage.
AI Snips
Chapters
Transcript
Episode notes
Gastric Cancer Risk Factors
- Gastric cancer risk factors include H. pylori infection and loss of CDH1 (E-cadherin), linked to diffuse type gastric cancer.
- High salt preservation foods are historic risk factors but less relevant now due to refrigeration.
Comprehensive Diagnostic Workup
- Perform a thorough workup including EGD with biopsy, EUS for invasion depth, and CT chest/abdomen/pelvis to stage gastric cancer.
- Consider laparoscopy with cytology and PET scan for T1B or higher tumors to identify metastatic disease.
TNM Staging Essentials
- Stage gastric cancer by tumor invasion depth (T), number of involved lymph nodes (N), and presence of metastasis (M).
- Memorize T2 as invasion into muscularis propria and N staging as N1:1-2, N2:3-6, N3:7+ lymph nodes.