In this interview, dementia expert Gil D. Rabinovici, MD, discusses monoclonal antibodies that target beta-amyloid–-including a recent phase 3 trial of donanemab published in JAMA-–and reviews considerations for their use in patients with Alzheimer disease. Related Content: Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease Donanemab in Early Symptomatic Alzheimer Disease

Interview with Katrina E. Donahue, MD, MPH, USPSTF member and coauthor of Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Reaffirmation Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Folic Acid Supplementation to Prevent Neural Tube Defects Folic Acid Supplementation to Prevent Neural Tube Defects Fully Effective Folic Acid Fortification Reaffirming Recommendations for Folic Acid Supplementation Folic Acid to Prevent Neural Tube Defects

JAMA Associate Editor David L. Simel, MD, MHS, discusses the latest European Society of Intensive Care Medicine (ESICM) Guidelines on Acute Respiratory Distress Syndrome, which were released in June 2023, with Derek C. Angus, MD, MPH, University of Pittsburgh. Related Content: Caring for Patients With Acute Respiratory Distress Syndrome

Interview with Li Li, MD, PhD, MPH, USPSTF member and coauthor of Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Lipid Disorders in Children and Adolescents Screening for Lipid Disorders in Children and Adolescents Still “on the Fence” About Universal Childhood Lipid Screening Screening for Lipid Disorders in Children and Adolescents

The incidence of Cushing syndrome due to endogenous overproduction of cortisol is 2 to 8 people per million annually. JAMA Deputy Editor Mary M. McDermott, MD, discusses diagnosis, management, and treatment of this condition with authors Martin Reincke, MD, from University of Munich, and Maria Fleseriu, MD, from Oregon Health and Science University. Related Content: Cushing Syndrome

The 2021 US maternal mortality rate is more than 10 times the rate of other high-income countries, according to a March 2023 CDC report. In this Q&A, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, is joined by Monica McLemore, PhD, MPH, RN, University of Washington, Audra Meadows, MD, MPH, UC San Diego, and Joia Crear-Perry, MD, founder and president of the National Birth Equity Collaborative, to discuss these concerning numbers and why preventable death rates are worsening in the US. Related Content: Trends in State-Level Maternal Mortality by Racial and Ethnic Group in the United States Worsening US Maternal Death Rates US Maternal Mortality Is Unacceptably High, Unequal, and Getting Worse—What Can Be Done About It? Trends in Maternal Mortality and Severe Maternal Morbidity During Delivery-Related Hospitalizations in the United States, 2008 to 2021

Interview with Michael Silverstein, MD, MPH, USPSTF chair and coauthor of Screening for Depression and Suicide Risk in Adults, and Screening for Anxiety Disorders in Adults: US Preventive Services Task Force Recommendation Statements. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Anxiety Screening Depression and Suicide Risk Screening Screening for Depression and Suicide Risk in Adults Screening for Anxiety Disorders in Adults Screening for Depression and Suicide Risk in Adults Screening for Anxiety Disorders in Adults Are There Reasons to Fear Anxiety Screening? Reframing the Key Questions Regarding Screening for Suicide Risk

JAMA Senior Editor Kristin Walter, MD, MS, speaks with Fernando Zampieri, MD, PhD, assistant professor in the Department of Critical Care Medicine at the University of Alberta in Alberta, Canada, about fluid therapy in critically ill adults with sepsis. Related Content: Fluid Therapy for Critically Ill Adults With Sepsis

Transgender and gender diverse persons may desire gender-affirming medical and surgical treatment that can mitigate psychologic distress and reduce suicide risk. JAMA Associate Editor David L. Simel, MD, MHS, speaks with Andrew M. Davis, MD, MPH, University of Chicago, and Tonia Poteat, PhD, PA-C, MPH, University of North Carolina, Chapel Hill, about the Standards of Care for the Health of Transgender and Gender Diverse People, Version 8 guidelines. Related Content: Standards of Care for Transgender and Gender Diverse People

Prevalence and causes of cirrhosis in the US, declining prevalence of hepatitis C. Usefulness of history and additional tests in diagnosing cirrhosis. Strategies to improve survival and quality of life for patients with compensated cirrhosis. Management of common symptoms and complications in cirrhosis.