JAMA Clinical Reviews cover image

JAMA Clinical Reviews

Obesity Medications

Jul 22, 2024
Dr. Robert F. Kushner from Northwestern University discusses new weight-loss drugs for obesity management. Topics include nutrient-stimulated hormone-based meds, less common medications, comparing terzepatide to semaglutide, and future weight loss drug advancements. The focus is on improving overall health outcomes with successful interventions.
17:54

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Quick takeaways

  • New weight-loss drugs target multiple mechanisms for appetite suppression, revolutionizing obesity management.
  • Patients on weight loss drugs must manage gastrointestinal side effects through diet adjustments and gradual dose increases.

Deep dives

Newer Weight Loss Drugs Mimic Entero-Pancreatic Hormones

These newer weight loss drugs mimic entero-pancreatic hormones like GLP-1 and amylin to suppress appetite effectively. Originally developed for diabetes treatment, these medications have multiple targets beyond the brain for appetite reduction, representing a significant advancement in obesity management. Candidates for these drugs are individuals with obesity (BMI 30 or greater) or BMI 27+ with medical complications like hypertension. Selection between drugs like liraglutide, semaglutide, and terzepatide depends on accessibility and affordability, with semaglutide and terzepatide showing high effectiveness in achieving weight loss.

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