JAMA Clinical Reviews

Obesity affects approximately 42% of adults in the US. Multiple strategies are available to treat obesity, including behavior therapies, GLP-1 receptor agonists, and bariatric surgery. Therapies vary in effectiveness and risks. JAMA Deputy Editor Mary McGrae McDermott, MD, discusses evidence-based obesity treatment with Melanie Jay, MD, MS, New York University Grossman School of Medicine. Related Content: Obesity Management in Adults As Semaglutide’s Popularity Soars, Rare but Serious Adverse Effects Are Emerging FDA Green-Lights Tirzepatide, Marketed as Zepbound, for Chronic Weight Management

Critical bleeding is associated with a high mortality rate in patients with trauma. JAMA Associate Editor Christopher W. Seymour, MD, MSc, discuses the results of the CRYOSTAT-2 trial with Nicola Curry, MD, Oxford University Hospitals, and Ross Davenport, PhD, Centre for Trauma Sciences, UK. Related Content: Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury

In July 2023, the US Food and Drug Administration (FDA) approved the first oral contraceptive pill (Opill) that will be available without a prescription. JAMA Senior Editor Kristin Walter, MD, MS, spoke with JAMA Associate Editor Melissa A. Simon, MD, MPH, about the use, effectiveness, and potential side effects of Opill. Related Content: Over-the-Counter Progestin-Only Oral Contraceptives

Interview with John M. Ruiz, PhD, USPSTF member and coauthor of Screening and Preventive Interventions for Oral Health in Children and Adolescents Aged 5 to 17 Years, and Screening and Preventive Interventions for Oral Health in Adults: US Preventive Services Task Force Recommendation Statements. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening, Referral, Behavioral Counseling, and Preventive Interventions for Oral Health in Children and Adolescents Aged 5 to 17 Years Screening and Preventive Interventions for Oral Health in Children and Adolescents Aged 5 to 17 Years Screening and Preventive Interventions for Oral Health in Adults A Call for More Oral Health Research in Primary Care Dental Caries in Adults, Adolescents, and Children Screening, Referral, Behavioral Counseling, and Preventive Interventions for Oral Health in Adults

The podcast discusses common causes of knee pain such as osteoarthritis, patellofemoral pain syndrome, and meniscal tears. It covers first-line treatments including therapeutic exercise, physical activity promotion, weight loss, and anti-inflammatories. The effectiveness of total knee replacement for knee osteoarthritis is also explored. Prognosis for patellofemoral pain and meniscal tears is discussed, highlighting the benefits of appropriate treatment and exercise therapy.

Hyperthyroidism affects 2.5% of adults worldwide and, if untreated, is associated with osteoporosis, heart rhythm abnormalities, heart failure, and increased mortality. JAMA Associate Editor Anne Cappola, MD, speaks with Elizabeth N. Pearce, MD, MSc, of Boston University, about the most common causes, symptoms, and first-line treatments for hyperthyroidism. Related Content: Hyperthyroidism

Preexposure prophylaxis (PrEP) and postexposure prophylaxis have recently gotten attention as ways to prevent sexually transmitted infections. JAMA Deputy Editor Preeti Malani, MD, MSJ, discusses postexposure prophylaxis using doxycycline (doxyPEP), with Kenneth H. Mayer, MD, professor of medicine and global health at Harvard and medical research director at Fenway Health in Boston. Related Content: Doxycycline Postexposure Prophylaxis and Sexually Transmitted Infections

Vasomotor symptoms are common during menopause and may have substantial negative effects on quality of life. JAMA Senior Editor Linda Brubaker, MD, MS, discusses nonhormonal therapies for menopausal vasomotor symptoms with Susan D. Reed, MD, MPH, MS, professor emeritus at the University of Washington and president and CEO of The North American Menopause Society. Related Content: Nonhormonal Therapies for Menopausal Vasomotor Symptoms

Approximately 500 000 adults in the US have survived childhood cancer. JAMA Deputy Editor Mary McGrae McDermott, MD, speaks with Smita Bhatia, MD, MPH, University of Alabama, about common medical problems that occur in adults who have survived a childhood cancer and optimal approaches to medical care for these patients. Related Content: Clinical Care for People Who Survive Childhood Cancer

Interview with Esa M. Davis, MD, MPH, USPSTF member and coauthor of Screening for Hypertensive Disorders of Pregnancy: US Preventive Services Task Force Final Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. Related Content: Screening for Hypertensive Disorders of Pregnancy Screening for Hypertensive Disorders of Pregnancy Hypertension Screening in Pregnancy Screening for High Blood Pressure Disorders During Pregnancy