Exploring neurological complications of systemic cancer therapies, including chemotherapy-induced neurotoxicity, immune checkpoint inhibitors, and CAR-T cell therapy. Discussion on monitoring and managing neurotoxicity post-treatment, immune reconstitution inflammatory syndrome, and challenges in treating complications.

This podcast explores nonvasculitic vasculopathies in cerebrovascular disease with in-depth discussions on extracranial atherosclerosis, vessel dissections, Horner's syndrome, sympathetic deficits, vasospasms, and treatment options. It also covers cerebral vasculopathies like CADASIL and cerebral amyloid angiopathy, along with diagnostic and treatment approaches for nonvasculitic vasculopathies.

Discussion on updates and considerations for determining brain death, including simulation-based training, criteria for testing, brain death risk score, and use of validated tools in brain death determination.

Explore the topics of neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein-associated disease (MOGAD). Learn about the historical background and classification of neuromyelitis optica, the clinical features and diagnostic criteria of Devic syndrome, treatment options for NMOSD and MOGAD, an overview of NMOSD and MOG-associated disorders, disease-modifying therapies for myelin-oligodendrocyte glycoprotein-associated disease, and a comparison of MOGAD, NMOSD, and MS.

Discussion on inflammatory polyneuropathies, focusing on Guillaume Bresindrum and its clinical presentation. Exploring AIDP pathophysiology, examination findings, diagnostic testing, and treatment options. Various variants of Guillain-Barre syndrome discussed, including clinical differences, nerve conduction studies, and antibody-associated syndromes.

A discussion on myasthenia gravis pathophysiology and diagnostic testing, including antibody disruptions at the neuromuscular junction. Treatment approaches for myasthenic crisis, respiratory monitoring, and long-term management with newer medications. Bedside examination maneuvers for respiratory and bulbar function assessment emphasized.

Discover the world of mitochondrial diseases affecting the nervous system with a focus on various syndromes and disorders like MELAS, Kearns Sayre Syndrome, Leber Hereditary Optic Neuropathy, and MERRF. Explore the genetic mutations, symptoms, diagnostic tools, and treatment options for these rare conditions.

Discover insights on various infections affecting the spinal cord and peripheral nervous system, from VZV and EVV disorders to rare parasitic infections. Explore clinical aspects of Lyme disease, neurological disorders overview, and infectious myositis like trichinosis. Uncover muscle infections in influenza and bacterial abscesses, emphasizing the role of neurologists in diagnosis and treatment.

An overview of headache syndromes associated with both high and low intracranial and CSF pressure, with Dr. Harry Sutherland and Christopher Gottschalk.  Note: This podcast is intended solely as an educational tool for learners, especially neurology residents. The contents should not be interpreted as medical advice.References and Additional ReadingSchievink WI. Spontaneous Spinal Cerebrospinal Fluid Leaks and Intracranial Hypotension. JAMA. 2006;295(19):2286–2296. doi:10.1001/jama.295.19.2286Dobrocky T, Grunder L, Breiding PS, et al. Assessing Spinal Cerebrospinal Fluid Leaks in Spontaneous Intracranial Hypotension With a Scoring System Based on Brain Magnetic Resonance Imaging Findings. JAMA Neurol. 2019 May 1;76(5):580-587. doi: 10.1001/jamaneurol.2018.4921.

Delve into language and speech complexities with Dr. Hillis, exploring brain regions and disorders post-stroke. Learn about aphasia syndromes, thalamic aphasia, progressive aphasias, apraxia of speech, and dysarthria evaluation techniques.