Neurology Exam Prep Podcast Episode 60 - Inflammatory Polyneuropathies
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Sep 2, 2023 Discussion on inflammatory polyneuropathies, focusing on Guillaume Bresindrum and its clinical presentation. Exploring AIDP pathophysiology, examination findings, diagnostic testing, and treatment options. Various variants of Guillain-Barre syndrome discussed, including clinical differences, nerve conduction studies, and antibody-associated syndromes.
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GBS Clinical Presentation
- Guillain-Barré Syndrome (GBS) typically presents as progressive, ascending, flaccid weakness and areflexia.
- Patients often report a preceding infection, commonly Campylobacter or a viral illness.
GBS Pathophysiology
- GBS pathophysiology involves autoantibodies disrupting the myelin sheath, primarily in demyelinating forms.
- These autoantibodies, often gangliosides, target the myelin, leading to its damage.
GBS Physical Exam
- Look for relative symmetry in GBS; marked asymmetry suggests a different diagnosis.
- Early bowel/bladder issues or a sensory level points to a potential spinal cord process.