Charles Brenner, PhD, discusses debunking longevity myths, NAD metabolism, calorie restriction, importance of skeletal muscle for healthy aging, personalized dietary choices, challenges of extending lifespan, benefits of NR supplementation, individualized nutrition approaches, impact of calorie restriction on longevity, maintaining healthy weight, significance of physical activity, dietary protein for aging, NAD boosters, functional tests in aging evaluation, testosterone replacement therapy for rejuvenation.

Episode #272. In the quest for an extended lifespan, has science been led astray? Join me as I sit down with Professor Charles Brenner, a leading global expert in NAD biology, to examine the longevity field's claims and controversies.From debunking common beliefs to questioning high-profile opinions, Dr Brenner delivers a refreshingly candid perspective on the science of aging. Tune in to explore why he believes there's no “cure” for aging, the limitations of animal studies, and what the future might hold for this complex field.Specifically, we discuss: Intro (00:00) Do we have the genes to live beyond 120 years? (3:54) The genetics of extreme longevity (14:18) Longevity in the animal kingdom (18:26) Why do we age, and the realities of extending lifespan (31:22) How long can we live? (39:01) NAD coenzymes and DNA repair (43:49) "Anti-ageing" products (55:17) Conflicts of interest and the integrity of scientific claims (1:01:08) Discovering nicotinamide riboside (NR) (vitamin B3) (1:03:19) Sirtuins as anti-ageing genes (1:09:22) A rebuttal to Drs. David Sinclair and Lenny Guarente (1:19:13) Seeking consensus on the study of human longevity (1:32:57) The information theory of aging (1:43:19) Dr. Charles Brenner's theory of ageing (2:00:28) How to age better (2:03:30) Dr. Brenner on the quality of life (2:09:05) NR supplementation (2:10:09) Moving beyond Yamanaka factors (2:15:02) Outro (2:18:45) Connect with Dr Charles Brenner on Twitter, and visit his website, https://www.brennerlab.net/, for more.Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon.Enjoy, friends.SimonWant to support the show?The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.Simon Hill, MSc, BSc (Hons)Creator of theproof.com and host of The Proof with Simon HillAuthor of The Proof is in the PlantsWatch the episodes on YouTube or listen on Apple/SpotifyConnect with me on Instagram, Twitter, and FacebookNourish your gut with my Plant-Based Ferments GuideDownload my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

This episode of Bulletproof Radio is all about living longer, better with the help of NAD (the coenzyme of life). Like Dave Asprey, Dr. Charles Brenner is someone who has really dug deep into what's going on in our mitochondria and is a total badass on all things related to cellular health.Charles is an expert on NAD and NADH and co-discovered something called Nicotinamide Riboside, which is one of the few compounds out there that can boost NAD in your body. And that is important if you are interested in aging better.If you can get your NAD levels up via any pathway possible - whether it is from exercise, eating the right things, or taking supplements - it is absolutely worth your time and attention if you are interested in living a more capable life for a longer period of time.Enjoy the show!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Charles Brenner, an expert on NAD metabolism and longevity supplements, joins the conversation to break down the science behind NAD and NMN. He explains how NAD coenzymes are crucial for energy metabolism and discusses their decline with age. The chat dives into the misconceptions surrounding these supplements and critiques popular longevity claims made by figures like Andrew Huberman and Peter Atiyah. Brenner emphasizes the importance of a healthy lifestyle over reliance on unproven treatments, making it clear that foundational health practices are essential.

The podcast discusses the benefits of boosting NAD+ for cellular repair and anti-aging, debunks longevity myths, explores NAD+ supplementation for health, and delves into topics like sustainable toothpaste, supplement industry complexities, and natural foot movement