Dr. Charles Brenner, PhD, discusses boosting NAD levels in cells for more energy and faster recovery. Topics include NAD's crucial role in metabolism, benefits of nicotinamide riboside, NAD's impact on stressed cells, tissue-specific NAD levels, and the complexities of NAD metabolism and NR supplementation. The conversation also touches on strategies for boosting NAD levels efficiently and sponsor mentions for Butcher Box and Public Goods.
Read more
AI Summary
AI Chapters
Episode notes
auto_awesome
Podcast summary created with Snipd AI
Quick takeaways
NAD coenzymes enhance anabolic processes for metabolic balance and health.
Nicotinamide riboside efficiently replenishes NAD stores in cells, beneficial for overall well-being.
Deep dives
Understanding the Importance of Nucleotides in Optimizing Health
Nucleotides play a crucial role in our health by serving as the building blocks for RNA and DNA. ATP and ADP work together to drive cellular machinery and produce energy. Dr. Brenner explains the significance of NAD coenzymes in metabolism and how supplementing with NAD can enhance anabolic processes in the body.
Exploring the Forms of NAD and Their Functions
There are four forms of NAD, including NAD+, NADH, NADP+, and NADPH, each serving distinct functions in metabolism. The discovery of Nicotinamide riboside (NR) as a vitamin precursor for NAD highlights its role in optimizing NAD levels across various tissues and cells, crucial for metabolic balance and overall health.
Addressing Concerns on Supplementing with NAD for Health Risks
Dr. Brenner addresses concerns regarding the potential risks of supplementing with NAD, particularly in relation to tumor growth. Studies have shown that NAD supplementation does not promote tumor growth; instead, it has exhibited protective effects in models of liver and breast cancer by enhancing DNA repair processes to maintain cellular integrity.
Distinguishing Different Forms of Vitamin B3 and the Role of NR
The podcast delves into the various forms of vitamin B3, such as Nicotinic acid, Niacinamide, and Nicotinamide riboside (NR). NR stands out as a crucial NAD precursor due to its efficient conversion into NAD and its ability to replenish NAD stores in cells universally, making it a valuable supplement for metabolic health and well-being.
Charles Brenner, PhD is the chair of the new Department of Diabetes & Cancer Metabolism at the Beckman Research Institute of the City of Hope National Medical Center. He is a major contributor to work on nicotinamide adenine dinucleotide metabolism, who discovered the eukaryotic nicotinamide riboside (NR) kinase pathway.
Get the Snipd podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share & Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode