The Peter Attia Drive #22 - Tom Dayspring, M.D., FACP, FNLA – Part III of V: HDL, reverse cholesterol transport, CETP inhibitors, and apolipoproteins
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Oct 17, 2018 
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Complexity of Reverse Cholesterol Transport
- Reverse cholesterol transport is far more complex than HDL simply bringing cholesterol back to the liver.
- HDL function varies, and HDL cholesterol levels do not accurately measure reverse cholesterol transport efficiency.
Apo Proteins Influence Lipoprotein Clearance
- LDL particles vary in their ApoE content, affecting clearance and atherogenicity.
- ApoC-III presence prolongs remnant lipoprotein residence time and increases coronary risk independent of LDL cholesterol.
Measure ApoC-III to Identify Risk
- Develop assays measuring apoC-III to better identify remnant lipoprotein risk.
- ApoC-III measurement could improve detection of atherogenic particles beyond traditional lipid metrics.