CRYOSTAT-2 Trial Presentation

Oct 12, 2023

Guest

Phil Gillen

Guest

Profs Nikki Curry and Karim Brohi present the results of the CRYOSTAT-2 trial, evaluating early and empiric high-dose cryoprecipitate in patients with major traumatic hemorrhage. The panel discusses the importance of fibrinogen in hemostasis, the feasibility and findings of the Cryostat treatment trial, comparing treatment against placebo in trauma trials, military trauma care, delays in analysis and caution with small sample sizes, and the discussion on formula composition and trial framework.

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Introduction

00:00 • 2min

The Importance of Fibrinogen in Hemostasis

02:20 • 29min

Feasibility and Findings of Cryostat Treatment Trial

31:14 • 22min

Comparing Treatment Against Placebo in Trauma Trials

53:21 • 12min

Military Trauma Care and the Importance of Fibrogen Replacement

01:05:47 • 17min

Delays in Analysis and Caution with Small Sample Sizes

01:22:28 • 5min

Discussion on Formula Composition, Trial Framework, and Patient Harm

01:27:03 • 3min