Profs Nikki Curry and Karim Brohi present the results of the CRYOSTAT-2 trial, evaluating early and empiric high-dose cryoprecipitate in patients with major traumatic hemorrhage. The panel discusses the importance of fibrinogen in hemostasis, the feasibility and findings of the Cryostat treatment trial, comparing treatment against placebo in trauma trials, military trauma care, delays in analysis and caution with small sample sizes, and the discussion on formula composition and trial framework.