Crucial Facts About Your Metabolism - Discussion Between Georgi Dinkov & Dr. Mercola
Sep 17, 2023
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Georgi Dinkov, biochemist, discusses human metabolism and aging. Topics include oxidation and reduction in human metabolism, the benefits and applications of methylene blue, the correlation between metal levels and metabolic disturbance, strategies for weight loss, the nutritional value of boiled potatoes, and the effects of certain substances on metabolism. They also explore the benefits of niacinamide, the effects of aspirin on lipolysis, the role of melatonin and sunlight in health, optimal protein intake, the role of cardiolipin in reverse electron flow, and the impact of meditation on cortisol levels.
Reductive stress, the excessive buildup of electrons, is a major contributor to aging and oxidative stress.
Contrary to the rate of living theory, slow metabolism and excess electrons lead to reactive oxygen species and accelerated aging.
Methylene blue is a potential solution to reducing reductive stress and improving metabolic rate.
Niacinamide, NAD+, and magnesium are crucial for metabolic function and ATP synthesis, while vitamin E acts as an antioxidant and supports fertility.
Deep dives
Summary of Main Ideas - Part 1
One complex concept discussed in the podcast is reductive stress, which challenges the conventional belief in oxidative stress as the main cause of aging. Reductive stress is described as the excessive buildup of electrons due to a blockage in the flow of electrons from food to oxygen. This leads to the generation of reactive oxygen species and the development of oxidative stress. The importance of understanding oxidation and reduction is emphasized in order to grasp the concept of reductive stress.
Summary of Main Ideas - Part 2
The rate of living theory, which suggests that a higher metabolic rate leads to increased oxidative stress and accelerated aging, is also discussed. However, the podcast presents evidence that contradicts this theory, stating that it is actually the slower metabolism and the buildup of excess electrons that result in the production of reactive oxygen species. The importance of addressing reductive stress and improving metabolic rate is highlighted as a key strategy to combat aging and oxidative stress.
Summary of Main Ideas - Part 3
Methylene blue is introduced as a potential solution to reducing reductive stress. It is described as a powerful metabolic uncoupler that can increase the metabolic rate and help dissipate excess electrons. Methylene blue is also thought to have various benefits, such as reducing reactive oxygen species, acting as an antioxidant, and potentially aiding in weight loss. The dosage and potential side effects of methylene blue are discussed, emphasizing the need for caution and appropriate usage.
Summary of Main Ideas - Part 4
Other strategies to address obesity are mentioned, including caffeine as a metabolic booster, cortisol blockers like RU486, and the importance of avoiding polyunsaturated fatty acids (PUFAs) while incorporating saturated fats like coconut oil. The significance of taking progesterone or pregnenolone alongside certain compounds, such as anabolic steroids or cortisol blockers, is also emphasized. Overall, improving metabolic rate and addressing reductive stress are presented as important factors in managing weight and promoting overall health.
Importance of Niacinamide and NAD+
Niacinamide and NAD+ are crucial for metabolic function and ATP synthesis. NAD+ activates the PDH enzyme, which is essential for proper metabolism. Niacinamide helps raise NAD+ levels, leading to higher ATP synthesis and improved metabolism. Magnesium is also important in this process, as it helps in ATP synthesis. Taking niacinamide with magnesium ensures better absorption and utilization of magnesium.
Benefits of Vitamin E and Glycine
Vitamin E is a powerful antioxidant that protects against oxidative stress and inhibits dangerous metabolites of polyunsaturated fats. It also acts as an antagonist to estrogen and supports fertility. The recommended dosage for vitamin E is around 100-150 mg per day, depending on the individual's intake of polyunsaturated fats. Glycine, on the other hand, has shown positive effects in reversing aging phenotypes in cell studies. A daily dose of about 10-12 grams of glycine can be achieved through supplementation or by consuming foods rich in glycine, such as gelatin.
Limitations and Potential Dangers of Cold Thermogenesis
Cold thermogenesis, such as ice baths or exposure to cold temperatures, is often promoted for its potential metabolic benefits. However, it can be stressful for the body and may have negative consequences. Cold thermogenesis raises cortisol levels and triggers a stress response, which can be counterproductive for overall health. Chronic exposure to extreme cold has been linked to premature aging in animal studies. It is not recommended as a safe or effective strategy for metabolic enhancement.
The Controversy around Meditation and Cortisol Reduction
Meditation has been touted as a method for reducing cortisol levels and managing stress. While some studies show positive effects, others indicate that meditation can worsen mental health issues for some individuals. Some extreme forms of meditation can lead to mental health problems, especially for inexperienced meditators. Additionally, meditation alone may not address the underlying causes of stress. It is important to approach meditation with caution and seek professional guidance if necessary.
