JAMA Clinical Reviews

Acute Pericarditis

40 snips
Sep 5, 2024
Paul C. Cremer, MD, MS, a JAMA Review author with expertise in acute pericarditis, joins David L. Simel, MD, MHS, JAMA's Associate Editor. They delve into the complexities of acute pericarditis, discussing its common presentation and diagnostic challenges, including the significance of pericardial friction rubs. The conversation highlights effective treatments, focusing on high-dose NSAIDs and colchicine, and emphasizes the importance of monitoring inflammation markers. Novel therapeutic options, including interleukin-1 blockers, are also introduced for recurrent cases.
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INSIGHT

Pericarditis Overview

  • Pericarditis involves inflammation of the pericardium, typically less than 1mm thick.
  • It comprises parietal (outer) and visceral (inner) layers, and inflammation causes fluid buildup and vascular changes.
INSIGHT

Symptoms

  • Chest pain in acute pericarditis is typically sharp, pleuritic, and worse when lying down.
  • Look for EKG changes, pericardial effusion, and friction rub to confirm the diagnosis.
ADVICE

Detecting a Friction Rub

  • To hear a pericardial friction rub, have the patient lean forward and listen.
  • Auscultate along the left sternal border at end expiration and during shallow inspiration.
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