Paul C. Cremer, MD, MS, a JAMA Review author with expertise in acute pericarditis, joins David L. Simel, MD, MHS, JAMA's Associate Editor. They delve into the complexities of acute pericarditis, discussing its common presentation and diagnostic challenges, including the significance of pericardial friction rubs. The conversation highlights effective treatments, focusing on high-dose NSAIDs and colchicine, and emphasizes the importance of monitoring inflammation markers. Novel therapeutic options, including interleukin-1 blockers, are also introduced for recurrent cases.

William Y. Kim, MD, a renowned expert from the University of North Carolina, joins JAMA Associate Editor David L. Simel, MD, MHS, to dive deep into renal cell carcinoma. They discuss groundbreaking links to Nobel-winning research on tumor suppressors and hypoxia-inducible factors. The conversation covers diagnostic challenges, genetic screening, and the importance of evaluating familial history. Treatment options are also highlighted, emphasizing advancements in surgical techniques and personalized therapies for advanced stages of the disease.