The 3 Phases of Fasting: And How to Get Kicked Out of Each One | Masterjohn Q&A Files #299

Sep 26, 2022

The podcast discusses the three phases of fasting and the transition from a fasted state to a fed state. It explores the depletion of liver glycogen and the shift to using ketones as fuel. The role of body signaling in transitioning between fasting states is also explained, along with the importance of preparatory signals when consuming food. The different stages of fasting and the changes that occur in the body during each phase are highlighted, including hepatic glycogen, gluconeogenesis, and ketones.

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Introduction

00:00 • 2min

The Three Phases of Fasting and Transition to Ketones as Fuel

02:20 • 6min

Understanding the Signaling and State Changes in Fasting

08:06 • 3min

Preparatory signals and phases of fasting

10:46 • 2min

The Three Phases of Fasting and the Importance of Signaling

12:57 • 2min

Short answer: 4-6 hours after a meal the small intestine is emptied and the insulin-to-glucagon ratio declines; 25 hours after, hepatic glycogen is emptied; 5 days later the brain is adapted to ketones and gluconeogenesis reaches its minimal level. Moving from one to the other cannot occur with a small piece of signaling like the bite of an apple. It requires the preponderance of signaling. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link:

https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions:

What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR?
Reversing Fatty Liver: How Long Does It Take?
What if my A1C says I'm diabetic but my CGM says I'm fine?
Will reishi, turmeric, or curcumin tank my testosterone?
The 3 Phases of Fasting: And How to Get Kicked Out of Each One

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the July 13, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included:

How do I know if my digestive enzymes are helping or hurting?
Why does high-dose glycine give me these terrible symptoms?
How to know if my magnesium is messing with my calcium?
Why do I have vitamin A symptoms when my lab tests are normal?
What is my favorite web site for finding enzymatic cofactors?
Potassium citrate vs potassium chloride
Major problems with B vitamin supplements
Is food sensitivity testing useful?
What nutrients might help with dihydropyrimidine dehydrogenase deficiency?
Does lipoic acid hurt methylation?
Sulfur SIBO that just won’t go away.
Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio.
Helping bile flow without pharmaceuticals.
Managing pernicious anemia.
Do we really need to meet the RDA for calcium?
Could stretch marks be a sign of copper toxicity?
When iron saturation is driven by low binding capacity.
How do I know if I need methyl-free Bs?
What causes heat intolerance? Here’s a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-de3

Access the show notes, transcript, and comments here.