The Immunology Podcast

Ep. 108: “The Intestinal Epithelium” Featuring Dr. Mahima Swamy

Jul 1, 2025
Guest
Mahima Swamy
Dr. Mahima Swamy, a Program Leader at the University of Dundee, shares her groundbreaking research on immune homeostasis in the intestinal epithelium. She delves into the intriguing functions of intestinal intraepithelial lymphocytes and their critical role in gut immunity. The discussion highlights the impact of LRRK2 on immune regulation linked to Crohn's and Parkinson's diseases, emphasizing how gut health affects neurological conditions. A playful analogy likens T-cell decision-making to superpowers, revealing their complex roles in nutrient uptake.
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INSIGHT

IELs Patrol and Protect Gut Epithelium

  • Intestinal intraepithelial lymphocytes (IELs) reside lifelong in the epithelial layer and constantly patrol it.
  • They interact mainly with epithelial cells to rapidly kill infected ones and promote epithelium shedding.
INSIGHT

IL-15 Activates IELs Locally

  • IL-15 is a key cytokine transpresented by epithelial cells to activate IELs.
  • Elevated IL-15 signals epithelial distress, triggering IEL proliferation and cytotoxic activity.
INSIGHT

IELs Drive Celiac Disease Damage

  • IELs can contribute to epithelial damage in celiac disease by responding to stress signals following CD4 T cell-mediated gluten recognition.
  • This leads to IEL-mediated destruction of epithelial cells in autoimmunity.
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