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Ep. 108: “The Intestinal Epithelium” Featuring Dr. Mahima Swamy

The Immunology Podcast

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Gut-Brain Connection: LRRK2 and T Cell Dynamics

This chapter explores the critical role of LRRK2 in immune regulation linked to Crohn's and Parkinson's diseases, emphasizing the relationship between gut health and neurological conditions. The discussion highlights the functions of various T cell populations in the intestinal epithelium, particularly focusing on their self-reactive nature and regulatory roles. Additionally, it examines the implications of gut microbiota and antibiotic exposure on the development and onset of Parkinson's symptoms.

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