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Ep. 108: “The Intestinal Epithelium” Featuring Dr. Mahima Swamy

The Immunology Podcast

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The Role of Intraepithelial Lymphocytes in Gut Immunity

This chapter explores the distinct functions of intraepithelial lymphocytes (IELs) within the intestinal epithelium and their interactions with epithelial cells. It highlights the critical role of cytokines, particularly IL-15 and IL-21, in activating IELs and mediating immune responses to infections and inflammatory conditions. The discussion also addresses the implications of IELs in the pathogenesis of disorders like inflammatory bowel diseases and celiac disease.

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