LONGEVITY with Nathalie Niddam #390: Muscle, Mitophagy, and Longevity: How Urolithin A Supports Healthy Aging and Athletic Performance With Brad Currier, PhD
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Nov 25, 2025 Dr. Brad Currier, chief scientist at Timeline Nutrition and a specialist in mitochondrial science, shares insights on aging and muscle health. He explains mitophagy's crucial role in muscle maintenance as we age and how elite athletes differ in mitochondrial efficiency compared to the general population. Currier discusses urolithin A's benefits, including enhancing strength and recovery, and its implications for skin and cognitive health. He outlines optimal dosing strategies and highlights the anti-inflammatory effects of Mitopure, offering a roadmap for healthier aging.
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Mitophagy Declines With Age
- Mitophagy is the selective recycling of dysfunctional mitochondria and declines with age.
- Restoring mitophagy can clear damaged mitochondria that otherwise accumulate and harm cellular function.
Exercise Preserves Mitochondrial Turnover
- Athletes maintain higher mitochondrial turnover because exercise elevates renewal processes.
- Sedentary people lack that stimulation and therefore accumulate dysfunctional mitochondria faster.
Stop Expecting Pomegranate To Deliver Urolithin A
- Don't rely on pomegranate juice to produce urolithin A because most people lack the converting gut microbes.
- Use direct urolithin A supplementation if you want consistent exposure and effects.