
The Resetter Podcast with Dr. Mindy How to Truly Age Like a Girl: a live chat with Dr. Mindy Pelz
Sep 22, 2025
Menopause is portrayed as a transformative phase in women's lives rather than just a health challenge. Dr. Mindy dives into how neurological shifts during this time can spark leadership and personal growth. She discusses the evolutionary benefits of menopause and the grandmother hypothesis, showcasing its societal importance. Insightful recommendations are offered on how lifestyle adjustments can restore neurochemistry. Emphasis is placed on educating families and clinicians to honor this vital stage, fostering a supportive community around menopause.
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Menopause As An Evolutionary Reboot
- Menopause is not a mistake but an adaptive life stage preparing women for new roles and purpose.
- Dr. Mindy Pelz links long post-reproductive lifespan to evolutionary purpose and leadership emergence.
Brain Remodeling Toward Leadership
- Menopause remodels the brain by pruning people-pleasing circuits and growing leadership-oriented networks.
- Lisa Mosconi's work and the grandmother hypothesis explain this neurobiological shift toward purpose.
Estrogen's 'Girl Gang' Of Neurochemicals
- Estrogen stimulates a network of ~12 neurochemicals that regulate memory, mood, sleep, and connective behavior.
- When estrogen declines these neurochemicals drop too, producing memory loss, insomnia, low mood, and disconnection.









