#04: Endotoxin, Otto Warburg, Cancer, Ketosis, and PUFA with Georgi Dinkov
Jun 14, 2019
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Georgi Dinkov specializes in Endotoxin, Otto Warburg, Cancer, Ketosis, and PUFA. Interesting topics include the controversy surrounding resveratrol, the obesity paradox, the connection between intellectual humility and energy levels, hair growth and cortisol levels, differences between vitamin K2 MK7 and MK4, and the use of chlorine dioxide as an antibiotic.
Increasing fatty acid oxidation does not result in weight or fat loss, challenging the common notion that it is the key to losing weight.
The obesity paradox challenges the belief that thinner is always healthier, as studies show lower all-cause mortality in overweight or obese individuals.
Metformin, a commonly used diabetes drug, can actually increase the risk of developing and worsening cancer.
Acidosis, characterized by excessive lactic acid production, is a sufficient and necessary condition for cancer development.
Starting with introductory books and utilizing resources like Khan Academy can help gain a basic understanding of biochemistry and physiology.
Collagen hydrolysate is more easily digestible than gelatin, but it may be produced with toxic acids.
Deep dives
Increased Fatty Acid Oxidation Does Not Lead to Fat Loss
A recent study revealed that increasing fatty acid oxidation does not result in weight or fat loss. In fact, the study found that when fatty acid oxidation was increased, glucose oxidation decreased by the same amount, leading to no significant weight loss. The researchers also noted that increasing fatty acid oxidation can have detrimental effects on the liver, potentially leading to insulin resistance. This challenges the common notion that increasing fatty acid oxidation is the key to losing weight, and suggests that alternative methods should be explored.
The Obesity Paradox
The obesity paradox refers to the phenomenon uncovered by epidemiological studies that demonstrate a lower all-cause mortality in individuals who are categorized as overweight or obese, compared to those with a normal BMI. Contrary to mainstream views, these studies have shown that being overweight or obese can offer protection against various diseases, including cancer, heart failure, and stroke. The obesity paradox challenges the common belief that thinner is always healthier, and highlights the need to reconsider current weight-related health guidelines and recommendations.
Metformin and Cancer Risk
Metformin, a commonly used drug for diabetes management, has gained popularity as a potential anti-aging and anti-cancer agent. However, recent studies have shown that metformin can actually increase the risk of developing and worsening cancer, especially under conditions of acidosis, where lactate production is increased. The metabolic effects of metformin can lead to elevated reverse T3 levels, resulting in poor thyroid function and metabolic suppression. This highlights the importance of understanding the potential risks and effects of medications commonly used in disease management.
The Acidosis-Cancer Link
Acidosis, characterized by the excessive production of lactic acid, has been found to be a sufficient and necessary condition for cancer development. Acidosis triggers metabolic changes in the body, leading to increased fatty acid oxidation and decreased glucose oxidation. This metabolic shift not only fuels cancer growth, but also inhibits liver function and disrupts normal thyroid hormone production. Acidosis can be induced by various factors, including excessive fatty acid oxidation, fasting, and certain medications, highlighting the need for a balanced and optimal metabolic environment for overall health and disease prevention.
The listener can begin by reading an introductory book on biochemistry or physiology to gain a basic understanding of the terminology and concepts.
Khan Academy is also a helpful resource with a library of videos on physiology, biochemistry, and metabolism.
As for reading research papers, it is recommended to start with experimental reports.
One book that may be beneficial is "Endocrine Physiology" by Constance R. Martin.
This book aligns with Ray Peat's perspective and delves into topics like estrogen, prostaglandins, prolactin, and cortisol.
Additionally, highlighting relevant information from the book and cross-checking it with Ray Peat's teachings can be a helpful way to reinforce knowledge and understanding.
Effects of Hydrolyzed Collagen vs. Gelatin
Collagen hydrolysate is more easily digestible than gelatin but may be produced with toxic acids. Gelatin itself is safe to consume.
Potential Causes of Vaney Eyes
Possible causes of vaney eyes include endotoxin, nitric oxide, lactic acid, and higher estrogen levels.
Regulating Sleep with Cortisol and Dysbiosis
If cortisol is elevated due to dysbiosis, cortisone transdermally may not be wise. Address gut dysbiosis first.
Using Phosphorus and Calcium Ratio in Dairy
Consuming dairy with a balanced ratio of phosphorus to calcium is generally safe. Phosphorus excess can be countered by avoiding meat and adding fructose or niacinamide to the diet.
