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Discovery of Mixed Feedback in Neurons
- Rodolphe Sepulchre discovered neurons' mixed positive and negative feedback by simplifying a computational model.
- This insight linked calcium channels to a broader, multi-scale feedback control motif.
Balance Defines Neural Functionality
- Balancing positive and negative feedback in neurons allows continuous control between memory and processing modes.
- This boundary, a mathematical singularity, underlies ultrassensitivity and spiking behavior.
Robustness in Mixed Feedback Control
- Mixed feedback systems exhibit robustness due to a narrow positive feedback range embedded in broad negative feedback.
- This design principle ensures spike behavior persists despite parameter uncertainty.