Brain Inspired
Paul Middlebrooks
Neuroscience and artificial intelligence work better together. Brain inspired is a celebration and exploration of the ideas driving our progress to understand intelligence. I interview experts about their work at the interface of neuroscience, artificial intelligence, cognitive science, philosophy, psychology, and more: the symbiosis of these overlapping fields, how they inform each other, where they differ, what the past brought us, and what the future brings. Topics include computational neuroscience, supervised machine learning, unsupervised learning, reinforcement learning, deep learning, convolutional and recurrent neural networks, decision-making science, AI agents, backpropagation, credit assignment, neuroengineering, neuromorphics, emergence, philosophy of mind, consciousness, general AI, spiking neural networks, data science, and a lot more. The podcast is not produced for a general audience. Instead, it aims to educate, challenge, inspire, and hopefully entertain those interested in learning more about neuroscience and AI.
Episodes
Mentioned books
22 snips
Dec 17, 2025 • 1h 15min
BI 227 Decoding Memories: Aspirational Neuroscience 2025
In this insightful discussion, guests Randal Koene, a computational neuroscientist, and Sven Dorkenwald, a research fellow at the Allen Institute, tackle the challenge of decoding non-trivial memories from static brain maps. They explore the feasibility of focusing on specific brain regions like the hippocampus rather than whole-brain scans. The panel debates the role of glial cells in memory and suggests using model organisms like songbirds for targeted experiments. They even speculate on timelines for achieving these ambitious breakthroughs in neuroscience.
6 snips
Dec 3, 2025 • 1h 36min
BI 226 Tatiana Engel: The High and Low Dimensional Brain
Tatiana Engel is a computational neuroscientist at Princeton, focusing on neural manifolds and brain dynamics. She unveils how latent circuits connect complex cognitive functions with neural connectivity. Discussing the International Brain Laboratory, she explains its mission to standardize data sharing, enhancing collaboration in neuroscience. Tatiana also explores the surprising finding of longer timescales in subcortical neurons compared to the cortex, revealing universal patterns across brain regions. Her insights bridge theoretical models and practical applications in understanding brain activity.
17 snips
Nov 19, 2025 • 1h 44min
BI 225 Henk De Regt: Understanding in Machines and Humans
In this discussion with Henk De Regt, a Professor of Philosophy of Science, listeners explore the nature of understanding in both humans and machines. Henk emphasizes that genuine scientific understanding hinges on both theory and contextual skills. He delves into the historical neglect of understanding in favor of explanation, and tackles whether machines can possess understanding through behavior-based benchmarks. The conversation also touches on the importance of metaphors, the degrees of understanding, and how public comprehension differs from expert insight.
38 snips
Nov 5, 2025 • 1h 49min
BI 224 Dan Nicholson: Schrödinger’s What is Life? Revisited
Dan Nicholson, Assistant Professor of Philosophy at George Mason University, delves into the nuances of Erwin Schrödinger's influential work, What Is Life? Revisited. They explore Schrödinger's motivations and how his physics background shaped his perspective on biology. Nicholson critiques the mechanistic view of cells, arguing genetic determinism misinterprets Schrödinger's ideas. He emphasizes the importance of a pluralistic approach to understanding biology, warning against overreliance on metaphors. Archival discoveries unveil Schrödinger's intent to clarify misconceptions about indeterminacy in biology.
4 snips
Oct 22, 2025 • 1h 39min
BI 223 Vicente Raja: Ecological Psychology Motifs in Neuroscience
Vicente Raja, a philosopher and cognitive scientist at the University of Murcia, explores ecological psychology, focusing on perception, affordances, and behavior in organisms and plants. He discusses the idea of 'motifs'—imprecise yet useful concepts that unify diverse scientific discussions. Vicente critiques traditional neuroscience's internal models, advocating for a perception-action approach instead. He also highlights innovative studies on plant behavior, demonstrating how climbing plants adjust their movements toward potential supports. This synthesis of philosophy and science offers a refreshing perspective on cognition.
31 snips
Oct 8, 2025 • 1h 28min
BI 222 Nikolay Kukushkin: Minds and Meaning from Nature’s Ideas
In this engaging discussion, Nikolay Kukushkin, an associate professor at NYU and senior scientist, delves into his book, *One Hand Clapping*, exploring the essences of nature and cognition. He shares the origins of his doodles as teaching tools that clarify complex ideas. The conversation touches on cellular memory, the evolution of brains, and the philosophical implications of AI as an extension of human thought. Kukushkin provocatively argues that meaning emerges from nature's patterns and urges a reevaluation of how we define memory and consciousness.
15 snips
Sep 24, 2025 • 1h 44min
BI 221 Ann Kennedy: Theory Beneath the Cortical Surface
Ann Kennedy, Associate Professor at Scripps Research and head of the Laboratory for Theoretical Neuroscience and Behavior, dives into the intriguing world of subcortical brain systems. She discusses how survival, threat response, and motivation are managed by these ancient circuits, even without cortical input. Ann emphasizes the importance of neural diversity for effective computation and explores how neuromodulatory signals shape behavior. Highlighting her innovative Kaggle competition, she also bridges behavioral analysis with theoretical neuroscience, connecting fundamental biology to advanced AI.
14 snips
Sep 10, 2025 • 1h 25min
BI 220 Michael Breakspear and Mac Shine: Dynamic Systems from Neurons to Brains
Michael Breakspear is a Professor of Systems Neuroscience in Australia, and Mac Shine runs the Shine Lab at the University of Sydney. They explore the dynamic systems from neurons to entire brains. The duo discusses how scaling from single neurons to networks impacts cognitive functions. They delve into the complexities of cerebellar neurons, emphasizing innovative technologies like deep learning and optogenetics. Their conversation highlights the interplay between arousal and performance through the Yerkes-Dodson law, revealing fascinating insights into neural dynamics and collaboration in neuroscience.
4 snips
Aug 27, 2025 • 1h 47min
BI 219 Xaq Pitkow: Principles and Constraints of Cognition
Xaq Pitkow, director of the Lab for the Algorithmic Brain at Carnegie Mellon University, dives into the principles of cognition and their applications. He shares insights on 'inverse rational control,' illustrating how organisms tackle tasks using strategies that often diverge from optimal solutions. The conversation covers the role of probabilistic graph networks in brain computations and introduces a new ecological neuroscience project with collaborative efforts. Xaq emphasizes the intersection of neuroscience and AI, advocating for a diverse range of models to understand cognitive processes.
20 snips
Aug 13, 2025 • 1h 47min
BI 218 Chris Rozell: Brain Stimulation and AI for Mental Disorders
Chris Rozell leads the Structured Information for Precision Neuroengineering Lab at Georgia Tech and is the inaugural director of the Institute for Neuroscience, Neurotechnology, and Society. He discusses groundbreaking methods using deep brain stimulation and AI to treat treatment-resistant depression. Chris highlights how neural signals can predict treatment effectiveness and the importance of personalized care in mental health. Their conversation delves into the evolving techniques in neuromodulation and the necessity of interdisciplinary research to enhance future therapies.
