The Internet Book of Critical Care Podcast IBCC Episode 104 - Hemophagocytic LymphoHistiocytosis (HLH)
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Nov 28, 2020 AI Snips
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HLH: A White Whale
- HLH, or hemophagocytic lymphohistiocytosis, is an immune disregulation involving runaway macrophages.
- It's a spectrum of illness, potentially overlapping with severe sepsis.
HLH Predisposition
- Secondary HLH likely involves a genetic predisposition triggered by infections or other factors.
- This differs from primary HLH, traditionally viewed as purely genetic.
Hemophagocytosis
- Hemophagocytosis, where macrophages consume blood cells, is a key feature of HLH.
- It's not very sensitive or specific, and better diagnostic markers are needed.