When to Use a Topside?

The topside is used to turn off the immune system. Traditionally, it's been a corner stone of therape for children with congenial h lh. The toxic profile here that i nedto about before i prescribe it? Yes, it can cause various organ toxicities. But knowing whether it's a top side in itself or the concomet multi organ failure from t e h l hs heart, that's the only thing i think we need to tilit ye.