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High Performance Health

Unlocking the Science of Aging: How to Eliminate ‘Zombie Cells’ for Longevity and Vitality | Dr Gregory Kelly

Nov 25, 2024
In this enlightening conversation, Dr. Gregory Kelly, a Naturopathic physician and expert in anti-aging, unravels the mysteries of senescent cells, or 'zombie cells,' which hinder health as we age. He introduces senolytics—compounds designed to clear these dysfunctional cells, enhancing vitality and energy. Dr. Kelly likens the process to pruning a plant for new growth, suggesting regular use of senolytics for those over 40. The discussion also highlights the importance of polyphenols in combating cellular aging and improving overall well-being.
48:21

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Quick takeaways

  • Senescent cells, or 'zombie cells,' accumulate with age and release inflammatory compounds that negatively affect overall health and cognitive function.
  • Senolytic compounds can help eliminate these dysfunctional cells, promoting healthier tissue function and improving vitality as we age.

Deep dives

Cellular Decision-Making and Senescent Cells

Every cell in the body continuously makes vital decisions about whether to remain functional or undergo apoptosis, which is a natural process of cell death. Senescent cells, often referred to as 'zombie cells', are those that resist apoptosis despite being stressed and unrepairable. These cells accumulate with age, failing to perform their intended function while releasing inflammatory compounds that contribute to various health issues. Consequently, the presence of senescent cells can disrupt tissue health, causing conditions such as cognitive decline and joint discomfort, primarily through their inflammatory effects.

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