ZOE Science & Nutrition

Do you want to die? How Bryan Johnson plans to cheat death

Mar 20, 2025

Bryan Johnson, an entrepreneur pouring millions into reversing aging, shares his groundbreaking health interventions. Joining him is Tim Spector, a leading expert in nutrition and the microbiome. They explore the surprising impact of sleep on longevity, debate the science behind health metrics, and unveil the potential of personalized nutrition. Johnson's controversial self-experiments, including blood transfusions and fecal transplants, add intrigue, while Spector highlights the importance of evidence-based food choices for optimal well-being.

01:06:30

Episode guests

Tim Spector

Bryan Johnson

AI Summary

AI Chapters

Episode notes

Podcast summary created with Snipd AI

Quick takeaways

Bryan Johnson utilizes meticulous tracking of over 50 health biomarkers to challenge aging and identify effective health interventions.

The podcast discusses the significant influence of lifestyle choices like diet and exercise on biological age, emphasizing that aging can be optimized.

Listeners are encouraged to adopt a personal experimentation approach in health management to discover tailored strategies for improved well-being.

Deep dives

The Quest for Perfect Health

Brian Johnson is dedicated to testing the boundaries of human health, spending $2 million annually and utilizing a team of 30 doctors in his pursuit of longevity. His initiative, Project Blueprint, seeks to explore whether it is possible for humans to halt aging and potentially avoid death altogether. By meticulously evaluating scientific literature related to healthspan and lifespan, he aims to adopt the most evidence-based therapies and metrics for health. Johnson claims to have achieved health markers better than 99% of 20-year-olds across various categories, underscoring the potential for significant life choice impacts on aging.

Intro

5min

Unlocking Longevity: The Project Blueprint

12min

Reimagining Existence: The Don't Die Framework

4min

Navigating Health Metrics and Self-Experimentation

15min

Exploring Personal Health Experiments through Food Tracking and Blood Transfusions

6min

Innovations in Health and Nutrition

20min

Exploring Personalized Health and Longevity Strategies

5min

Could optimizing your sleep significantly extend your lifespan?

In this episode, we dive deep into the science of longevity with Bryan Johnson, the entrepreneur spending millions to reverse aging, and Professor Tim Spector, one of the world’s top 100 most-cited scientists and an expert in nutrition and the microbiome.

Bryan has dedicated his life—and his body—to testing cutting-edge health interventions to slow down aging. His meticulous approach to sleep, diet, and exercise has sparked global debate.

But how much of it is backed by science? Tim Spector joins the conversation to separate fact from fiction, revealing what actually works when it comes to sleep, longevity, and optimizing health.

🥑 Make smarter food choices. Become a member at zoe.com - 10% off with code PODCAST

🌱 Try our new plant based wholefood supplement - Daily 30+

Follow ZOE on Instagram.

Timecodes

00:00 No.1 anti aging hack

02:05 Quickfire questions

04:01 Bryan’s longevity protocol

06:20 Biological age markers

08:16 How to measure aging

13:40 Can AI help stop aging?

18:50 What science can we trust?

21:40 Bryan’s self-experiments