

Deep dive into photobiomodulation (red light therapy) science with Dr. Mark Cronshaw
Feb 22, 2025
Dr. Mark Cronshaw, a leading expert in photobiomodulation with over 40 years in dentistry and laser research, dives deep into the science of red light therapy. He explains the biphasic dose response and its impact on cellular activity, pain relief, and inflammation. The discussion highlights mitochondrial dynamics and the balance between benefits and toxic byproducts of red light therapy. Additionally, he explores the evolutionary significance of photobiomodulation and its systemic effects, including brain health and the role of melanocytes in mood regulation.
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Early Red Light Panel Sourcing
- Ari Whitten used to reach out to marijuana growing light companies for custom red light panels.
- This was before the widespread availability of red light therapy devices.
Two Dose Windows in PBM
- Dr. Cronshaw's research revealed two dose windows for photobiomodulation.
- Lower doses stimulate cellular activity, while higher doses offer pain relief.
ROS and Cellular Activity
- Small amounts of reactive oxygen species (ROS) stimulate cell activity and growth factors.
- Excessive ROS can be toxic, highlighting the need for regulation.