Deep dive into photobiomodulation (red light therapy) science with Dr. Mark Cronshaw
Feb 22, 2025
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Dr. Mark Cronshaw, a leading expert in photobiomodulation with over 40 years in dentistry and laser research, dives deep into the science of red light therapy. He explains the biphasic dose response and its impact on cellular activity, pain relief, and inflammation. The discussion highlights mitochondrial dynamics and the balance between benefits and toxic byproducts of red light therapy. Additionally, he explores the evolutionary significance of photobiomodulation and its systemic effects, including brain health and the role of melanocytes in mood regulation.
Photobiomodulation (PBM) has gained mainstream recognition in health, transforming from a niche interest into an essential therapy offering in wellness centers.
The evolving science around PBM necessitates continuous updates and collaboration among experts, ensuring a comprehensive understanding of treatment mechanisms and dosimetry.
Ongoing debates regarding temperature modulation's impact during PBM treatments highlight the complexity of optimizing therapeutic outcomes in light therapy research.
Deep dives
The Rise of Photobiomodulation
Photobiomodulation (PBM) has transitioned from a niche area of interest to a mainstream topic in health, particularly through the popularity of red and near-infrared light therapy. Originally considered fringe, awareness and accessibility of this therapy have skyrocketed in recent years, with numerous clinics and wellness centers now incorporating it into their offerings. The speaker's journey into this field was catalyzed by discovering its unique effects on human biology through years of personal research, leading to the creation of a widely recognized book on the subject. This shift toward mainstream recognition underscores the potential benefits of PBM and the growing demand for updated resources to inform both practitioners and the general public.
Evolution of Knowledge and Research
Over time, as scientific understanding of PBM has advanced, the speaker has recognized the need to revise previous assumptions and research conclusions. The emergence of new information and techniques has necessitated an update to the initial book on red light therapy, which will include more scientifically rigorous content and a comprehensive overview of the evolving landscape of PBM. To enhance the book’s impact, various esteemed experts in the field have been consulted to share contrasting viewpoints and evidence, ensuring that readers receive a balanced perspective on the contentious issues surrounding PBM. This collaborative approach reflects a commitment to transparency and thorough research in the rapidly growing field.
Controversies in Photobiomodulation
A key focus in the field of PBM is the ongoing debate regarding optimal dosimetry and the differences between lasers and LEDs for therapeutic effects. The variety of opinions among researchers reflects the complexity and current infancy of PBM science, as different experts may hold firmly to conflicting beliefs about treatment parameters, device efficiencies, and application techniques. The speaker aims to demystify these disagreements in the upcoming book by presenting a range of expert views, allowing readers to better understand the various schools of thought. By addressing these controversies, the text aspires to contribute to a more nuanced understanding of PBM for both researchers and the public.
The Role of Temperature in Therapy
Temperature modulation during PBM treatments remains a contentious subject with implications for clinical efficacy. Some researchers argue that thermal effects can overshadow the benefits of light application, while others highlight that controlled heating may enhance therapeutic outcomes. Through careful examination of existing literature, potential mechanisms by which increased temperatures influence pain modulation, cellular stress responses, and healing processes can be elucidated. The ongoing exploration into how temperature interacts with light therapy offers valuable insights and underscores the importance of a holistic approach to understanding PBM treatments.
Future Directions in Photobiomodulation Research
The future of PBM research appears promising as new findings and innovative applications emerge, tantalizing the potential for home-based therapy devices. Researchers are working toward developing therapies that may empower individuals to self-administer targeted PBM treatments for various health conditions. Expanding the evidence supporting PBM can increase public awareness and acceptance, paving the way for further advancements in both clinical practice and consumer products. As the speaker continues their research and dialogues with other experts, the evolution of PBM will likely redefine its role in contemporary health and wellness paradigms.
In this episode, I’m speaking with Dr. Mark Cronshaw, a highly respected expert in the field of photobiomodulation (PBM) – what most people commonly think of as red light therapy.
This is the first of many podcasts with Dr. Cronshaw, who is one of the most brilliant and knowledgeable experts I’ve had the pleasure of connecting with on this topic. Our conversation goes deep into the science of photobiomodulation—there are some practical pearls that Dr. Cronshaw discusses, but be prepared for deep, nuanced, and technical scientific discussion about light therapy.
WARNING: Please be aware that this conversation with Dr. Cronshaw is NOT just a simple practical how-to guide of “go buy this device and use it this way.” This is a podcast series that intends to go deep into the scientific, technical, and theoretical nuances of PBM science. So it’s NOT for everyone. If you just want a simple practical how-to guide, we will eventually get there, but there are several hours of geeky technical science stuff before we get there. These podcasts with Dr. Cronshaw are for people who want to nerd out on PBM science. So please don’t say I didn’t warn you! :)
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