Episode #203: Everything You Need to Know About The Theory of Aging with Dr. Sandra Kaufmann

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Jan 9, 2024

Dr. Sandra Kaufmann discusses the critical functions of SIRT1 and SIRT3 in our bodies in the quest to combat aging. She explores supplement bioavailability, pitting resveratrol against pterostilbene, and discusses state-of-the-art delivery methods. We also dive into the tangible impacts of diet and supplementation on maintaining youthful vitality and sourcing quality products without breaking the bank.

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Introduction

00:00 • 4min

Understanding and Combating Aging at a Cellular Level

04:14 • 3min

Hiking the Grand Canyon and Understanding Histone Deacetylases

07:21 • 18min

DHM: A Potential Hangover Cure

25:24 • 5min

The Benefits of Fucodan for Anti-Aging

30:46 • 14min

Discussion about NAD precursors, bio regulator peptides, and Selbeck's

45:03 • 6min

The Role of Heat Shock Proteins and Chaperones in Cellular Function and Aging

51:02 • 12min

Insights on the Kauffman Line of Supplements and Future Plans

01:02:58 • 3min

What do you really know about the theory of aging?

In this episode of the Biohacking Superhuman Performance podcast, we chat with Dr. Sandra Kaufman about the critical functions of SIRT1 and SIRT3 in our bodies, spotlighting how these proteins are not only gatekeepers of DNA repair and mitochondrial efficiency but also promising targets in the quest to combat aging.

We dissect the intricacies of supplement bioavailability, pitting resveratrol against its molecular cousin pterostilbene. Dr. Kaufman demystifies recent findings and navigates us through state-of-the-art delivery methods that are revolutionizing the way our bodies absorb these longevity-boosting substances. Adding to the mix, we'll explore the vital role of SIRT1 activation and the myriad factors that contribute to mitochondrial health, reinforcing why this cellular powerhouse is synonymous with our overall well-being.

To cap off our enlightening discussion, we delve into the tangible impacts of diet and supplementation on maintaining youthful vitality. Dr. Kaufman shares her candid experiences—from the acquired tastes of traditional Chinese medicine teas to the powerful effects of fucoidan—and offers sage advice on sourcing quality products without breaking the bank.

Dr. Kaufmann began her academic career in the field of cellular biology, earning a Master’s Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. Turning to medicine, she received her medical Degree at the University of Maryland, and completed a residency and fellowship at Johns Hopkins in the field of pediatric anesthesiology. For the last five years she has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. Her avid interest in the science of anti-aging began many years ago as an intense hobby. Utilizing her knowledge in cell biology, human pharmacology and physiology, this hobby has now become a main focus. The project represents years of non-clinical research leading to the first, ever, comprehensive theory of aging.

What we discuss:

(00:02) - Exploring Sirtuins

(10:26) - Bioavailability and Activators for CERT1/3

(21:28) - Discussion on Foods and Supplements

(33:33) - Cellular Homeostasis and NAD

(40:02) - Cellbex and Heat Shock Proteins

(53:44) - Exploring Exosomes and Future Clinic

Thank you to our sponsors for making this episode possible:

Sensate: Go to https://www.getsensate.com and use code NAT

Beam Minerals: Go to https://www.beamminerals.com and use code Nathalie to get 20% off your order

Profound Health: Visit www.profound-health.com and use code longevity15 to save 15%

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