Hiking the Grand Canyon and Understanding Histone Deacetylases

In this chapter, Dr. Sandra Kaufmann shares her strategies for hiking the Grand Canyon and talks about her upcoming climb in Ecuador. The conversation then shifts to discussing the role of histone deacetylases in controlling gene expression and protein production. The chapter provides an in-depth understanding of histones, sirtuins, and their importance in cellular homeostasis.

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What do you really know about the theory of aging?

In this episode of the Biohacking Superhuman Performance podcast, we chat with Dr. Sandra Kaufman about the critical functions of SIRT1 and SIRT3 in our bodies, spotlighting how these proteins are not only gatekeepers of DNA repair and mitochondrial efficiency but also promising targets in the quest to combat aging.

We dissect the intricacies of supplement bioavailability, pitting resveratrol against its molecular cousin pterostilbene. Dr. Kaufman demystifies recent findings and navigates us through state-of-the-art delivery methods that are revolutionizing the way our bodies absorb these longevity-boosting substances. Adding to the mix, we'll explore the vital role of SIRT1 activation and the myriad factors that contribute to mitochondrial health, reinforcing why this cellular powerhouse is synonymous with our overall well-being.

To cap off our enlightening discussion, we delve into the tangible impacts of diet and supplementation on maintaining youthful vitality. Dr. Kaufman shares her candid experiences—from the acquired tastes of traditional Chinese medicine teas to the powerful effects of fucoidan—and offers sage advice on sourcing quality products without breaking the bank.

Dr. Kaufmann began her academic career in the field of cellular biology, earning a Master’s Degree from the University of Connecticut in Tropical Ecology and Plant Physiology. Turning to medicine, she received her medical Degree at the University of Maryland, and completed a residency and fellowship at Johns Hopkins in the field of pediatric anesthesiology. For the last five years she has been the Chief of Pediatric Anesthesia at the Joe DiMaggio Children’s Hospital. Her avid interest in the science of anti-aging began many years ago as an intense hobby. Utilizing her knowledge in cell biology, human pharmacology and physiology, this hobby has now become a main focus. The project represents years of non-clinical research leading to the first, ever, comprehensive theory of aging.

What we discuss:

(00:02) - Exploring Sirtuins

(10:26) - Bioavailability and Activators for CERT1/3

(21:28) - Discussion on Foods and Supplements

(33:33) - Cellular Homeostasis and NAD

(40:02) - Cellbex and Heat Shock Proteins

(53:44) - Exploring Exosomes and Future Clinic

Thank you to our sponsors for making this episode possible:

Sensate: Go to https://www.getsensate.com and use code NAT

Beam Minerals: Go to https://www.beamminerals.com and use code Nathalie to get 20% off your order

Profound Health: Visit www.profound-health.com and use code longevity15 to save 15%

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