How to Slow Down Your Biological Aging – Morgan Levine, Ph.D. : 941

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May 27, 2022

Morgan Levine, Ph.D., an expert in biological aging and director at Yale University’s Laboratory for Aging in Living Systems, discusses groundbreaking insights into aging. She emphasizes that biological age is a greater risk factor for diseases like Alzheimer’s than chronological age. The conversation delves into innovative approaches to measure biological age and the quest for reversing aging processes. Levine also highlights personalized ageotypes and the role of lifestyle choices in extending healthspan, merging science with the potential for improved longevity.

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INSIGHT

Biological vs. Chronological Age

Chronological age isn't as important as biological age, which reflects your body's true state.
Biological age is a better indicator of health and risk for age-related diseases.

INSIGHT

Measuring Biological Age

Biological age measures how much your body has aged, not just in chronological time.
Epigenetics, like chemical tags on DNA, can be used to measure biological age.

ANECDOTE

Alcohol and Aging

Dave Asprey experimented with alcohol consumption and observed its impact on his biological age.
He suggests that even small lifestyle changes can affect aging.

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IN THIS EPISODE OF THE HUMAN UPGRADE™...

…you’ll learn how biological age, rather than chronological age, is the primary risk factor behind diseases like cancer, heart disease, diabetes, strokes, even Alzheimer’s. Scientific discoveries show chronological aging may be written in the epigenome, those chemical tags attached to your DNA that control the way DNA operates.

We’re finding out more about both types of aging because of scientists like Morgan Levine, Ph.D., a leading voice in the field of aging and longevity science. She focuses her research on the science of biological aging, emphasizing health span over lifespan.

“If you take the difference between someone’s biological age and chronological age, it should predict the things we care about, the actual things we're trying to prevent—so death, disease,” she says.

She’s an assistant professor of pathology and the Director of the Laboratory for Aging in Living Systems at Yale University School of Medicine. Her team looks at using bioinformatics to quantify the aging process and test how lifestyle and pharmaceuticals alter the rate of aging.

She’s also a founding Principal Investigator at Altos Labs, a biotech company that focuses on cellular rejuvenation programming to restore cell health and resilience.

Today, she’s going to talk about the science of aging and longevity explored in her new book, “True Age: “Cutting-Edge Research to Help Turn Back the Clock.” Three main drivers—health behaviors, recent stressors and adversity, and genetics—determine your biological aging. She shares how to measure your own biological age and why you should track your aging regularly.

This conversation gets into topics and makes them make sense for your own aging, like:

Epigenetics & epigenetic clocks
DNA methylation & telomeres
Cell lifespan
Ageotypes (molecular assessment of aging)
Phenotypic age
The “Ceiling” effect
The “CALERIE” trial
Nutrition & aging (plants, fasting, ketosis)
Fitness & aging (energy & brain health)
Rest & relaxation (sleep & biological programming)

Morgan gives great takeaways on how you can make lifestyle changes to maintain your youthfulness—both inside and out—with low-risk, data-driven biohacking.

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