The Jesse Chappus Show

717: Neurologist: The Real Cause of Brain Disease — and How to Protect Yourself | Dr. David Perlmutter

Aug 11, 2026
Dr. David Perlmutter, a board-certified neurologist and bestselling author on brain health. He explores microglia and how metabolic dysfunction drives brain disease. The gut microbiome, ultra-processed foods, and lifestyle choices shape risk. Practical starts include diet, sleep, movement, targeted supplements, and emerging therapies like hyperbaric oxygen and GLP-1 drugs.
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ADVICE

Start One Small Change And Layer Progressively

  • Start small and pick one achievable behavior to build momentum (eg walk to the mailbox twice daily).
  • Layer changes gradually: add sleep tracking, then improve sleep hygiene, then address blood sugar and diet for sustainable gains.
ADVICE

Cut Ultra-Processed Foods To Lower Dementia Risk

  • Avoid ultra-processed foods: each extra daily serving increases dementia risk by ~13%.
  • People eating 10+ servings per day had nearly 2.7-fold higher dementia risk in a 12-year cohort study.
ADVICE

Read Ingredients To Spot Ultra-Processed Foods

  • Shop the grocery periphery and choose foods without ingredient lists or with ≤3 ingredients to avoid ultra-processed items.
  • Emulsifiers, added sweeteners and flavor enhancers are red flags; prefer whole produce, eggs, fish and unprocessed meats.
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