The Human Upgrade: Biohacking for Longevity & Performance

Memory, Psychedelics, and Biohacking with Dr. Manoj Doss : 1187

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Aug 6, 2024

Dr. Manoj Doss, a neuroscientist specializing in psychoactive drugs at UT Austin, shares groundbreaking insights on memory and psychedelics. He discusses how substances like THC and ketamine can disrupt and enhance memory processes, challenging traditional views. The episode explores the surprising effects of psychedelics on different kinds of memory and the role of the hippocampus. Dr. Doss also examines cognitive enhancers like nicotine, weighing their benefits and risks, while delving into the ethical implications of memory manipulation and trauma's impact on recollection.

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INSIGHT

How the Mind Works

Some people use the predictive processing framework to explain how the mind works.
The mind likely operates hierarchically, with increasing levels of abstraction.

ANECDOTE

Researchers Testing Psychedelics

Researchers tested psychedelic doses, with varied reactions.
One older researcher had a profound experience, saying "Oh God" before the camera cut off.

INSIGHT

Memory Stages and Drug Impact

Memory involves encoding, consolidation, and retrieval stages.
Drugs impact these stages differently, like alcohol enhancing memory if consumed post-study.

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In this episode of The Human Upgrade, Dr. Manoj Doss, a neuroscientist at the University of Texas at Austin Dell Medical School, explores the fascinating intersection of psychedelics, memory, and cognitive enhancement. Drawing from his extensive research, Dr. Doss dives into how psychoactive substances like THC, ketamine, and psychedelics can alter memory formation, consolidation, and retrieval. He challenges the conventional understanding of memory by revealing how these substances might disrupt traditional memory processes while potentially opening new pathways for learning and cognition.

You'll discover how different drugs impact your brain's ability to encode and recall information, the surprising effects of psychedelics on semantic and episodic memory, and the role of the hippocampus in shaping our personal narratives. Dr. Doss also delves into the potential benefits and risks of cognitive enhancers like nicotine and modafinil, offering insights into their effects on memory and brain function.

Dr. Doss provides a nuanced perspective on the malleability of memory, the ethical implications of memory manipulation, and the complex relationship between trauma, memory, and psychedelics. This episode is essential for anyone interested in the cutting-edge science of memory, the therapeutic potential of psychedelics, and the quest to enhance cognitive performance.

Timestamps:

00:00:01 — Opening
00:01:39 — Introduction to Dr. Manoj Doss
00:03:20 — The Impact of Psychedelics on Memory
00:05:50 — The Predictive Processing Framework and Mind Models
00:13:22 — Alcohol and Retrograde Facilitation: Enhancing Memory Post-Study
00:19:00 — Differences Between Episodic and Semantic Memory
00:22:57 — The Role of the Hippocampus in Memory Formation
00:32:35 — Exercise, BDNF, and Memory Enhancement
00:42:29 — The Complex Relationship Between Psychedelics and Neurogenesis
00:52:16 — The Fallibility of Memory and False Memory Formation
01:09:04 — The Influence of Nicotine, Modafinil, and Other Cognitive Enhancers
01:30:34 — Closing Remarks

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