The Mushroom Hour Podcast

Ep. 151: Neuroscience, Memory and Psychedelics (feat. Manoj Doss PhD)

Apr 17, 2023

02:08:31

Episode guests

Manoj Doss

AI Chapters

Episode notes

Introduction

2min

The Origin Story of Manoj's Research in Cognitive Neuroscience

3min

The Nuts and Bolts of Cognitive Neuroscience

3min

The Neurology of the Human Brain

3min

How to Structure Research on the Brain

3min

The Different Types of Memory

4min

The Effects of Psychedelics on Familiarity

2min

The Importance of Multiple Activations in Semantics

2min

The Effects of Memory Consolidation on Memory

3min

10.

The Episodic Memory of Memory

4min

11.

How to Recreate Memories

5min

12.

The Role of the Hippocampus in Memory Memory

4min

13.

The Effects of Non-Rem Sleep on the Brain

2min

14.

The Differentiation Between Conscious Processing and Other Operations of the Brain

4min

15.

The Effects of Trauma on Memory

3min

16.

The Importance of Receptors in Memory

2min

17.

How to Create a False Memory

4min

18.

The Role of Psychedelics in Memory

6min

19.

The Over Emphasis on the Default Mode Network in Psychedelics

3min

20.

The Hierarchy of Sensor Information in the Brain

2min

21.

The Effects of Psychedelics on the Brain

5min

22.

The Effects of Psychedelics on the Brain

5min

23.

The Importance of Humility in Memory and Perception

1min

24.

The Benefits of Psychedelics

6min

25.

The Role of Psychedelics in Anxiety

5min

26.

The Future of Psychedelic Therapy

4min

27.

Psychedelics and the Subjective Experience

6min

28.

The Effects of Psychedelics on Memory

2min

29.

The Semi-Permeable Self

3min

30.

Synthetically Produced Psilocybin

3min

31.

The Effects of Psilocybin on Nigrosis

4min

32.

The Importance of Balance in Psychedelic Research

3min

33.

The Cost of a Collective Unconscious

4min

34.

The Importance of Spirituality in Happiness

2min

35.

How Does Your Relationship With Mushrooms Change You?

4min

36.

The Effects of Foraging on the Brain

3min

37.

The Future of Psychedelic Substances

3min

Today on the Mushroom Hour Podcast we are blessed to speak with Manoj Doss. Manoj is a cognitive neuropsychopharmacologist at the Center for Psychedelic and Consciousness Research at Johns Hopkins University. His research is at the intersection of cognitive neuroscience and neuropsychopharmacology with focuses on episodic memory and hallucinogenic drugs. Manoj utilizes complex cognitive paradigms, brain imaging, and computational modelling to explore what makes psychedelics unique compared to other classes of psychoactive drugs, both in terms of basic drug effects and mechanisms for treating clinical populations. Although Manoj is optimistic that psychedelics will soon have a place in psychiatry, he remains cautious of exaggerated claims and negligence to potential downsides, something he terms 'psychedelic myopia’.

TOPICS COVERED:

Cognitive Neuroscience & Neuropsychopharmacology
Psychedelic Neuroscience
Types of Memory - Episodic, Semantic, Procedural
Parts of the Brain - Hippocampus, Neocortex
Recollection vs Familiarity
Psychedelics Impacting Memory through Familiarity
Is Memory Stored in Parts of the Body Other than the Brain?
How Do We Make False Memories?
Debunking the “Default Mode Network” Narrative
Psychedelic Science and Incorporating Existing Scientific Disciplines
Showing Psychedelics are Actually Useful in Treating Any Disorders
Commentary on Structuring Psychedelic Research
Future of Psychedelic Therapy as Adjunct to Existing Therapies?
Tempering Conclusions and Expectations from Psychedelic Research

EPISODE RESOURCES:

Manoj Doss Twitter: https://twitter.com/ManojDoss
Manoj Doss Researchgate: https://www.researchgate.net/profile/Manoj-Doss
Manoj Doss @ Johns Hopkins: https://hopkinspsychedelic.org/doss
John O'Keefe Nobel Prize work on Hippocampal place cells: https://www.nature.com/articles/s41586-022-04913-9
Doss et al paper on reward dynamics: http://dml.ucdavis.edu/uploads/6/1/9/7/61974117/gruber_ritchey_wang_doss_ranganath_2016.pdf
Default Mode Network Hypothesis: https://www.frontiersin.org/articles/10.3389/fnhum.2014.00020/full
PiHKAL: A Chemical Love Story by Alexander Shulgin: https://www.amazon.com/Pihkal-Chemical-Story-Alexander-Shulgin/dp/0963009605
Janice Chen paper on shared experience: https://scholar.google.com/citations?view_op=view_citation&hl=en&user=mOwF8UEAAAAJ&citation_for_view=mOwF8UEAAAAJ:M05iB0D1s5AC
Marc Berman paper on benefits of interacting with nature: https://journals.sagepub.com/doi/10.1111/j.1467-9280.2008.02225.x

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