The Peter Attia Drive #14 - Robert Lustig, M.D., M.S.L.: fructose, processed food, NAFLD, and changing the food system
01:23:17
Fructose's Potent Browning Effect
- Fructose and glucose differ significantly in metabolism and effects on the body.
- Fructose causes the browning reaction seven times faster, leading to more damage and aging.
Uric Acid Links Sugar to Hypertension
- Uric acid levels in blood rise with increased sugar consumption due to fructose metabolism.
- Elevated uric acid impairs endothelial function and raises blood pressure, linking sugar intake to cardiovascular risk.
ALT vs AST Liver Markers
- ALT and AST are liver enzymes that indicate different aspects of liver health.
- ALT correlates with liver fat and is a more stable biomarker than AST, which reflects mitochondrial function.
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Introduction
00:00 • 6min
The Impact of Fructos on Inflammation
05:51 • 2min
Glucose Is the Energy of Life
07:22 • 2min
The Browning Reaction Is What Makes People Age
08:59 • 2min
How to Measure Glucos Levels Through Hemoglobin
10:38 • 2min
Fructos and Glucos Are Not the Same the Food Industry Would Have You Believe
12:09 • 2min
Is Hemoglobin A, One C, a Surrgate Proxy?
13:49 • 1min
Is There a Glucose Transporter in the Liver?
15:18 • 2min
The Relationship Between Uric Acid and Sugar Consumption
16:54 • 2min
What's the Difference Between a L T and a S T?
18:26 • 2min
Is 25 the Upper Limit of Normal?
20:03 • 2min
The Endothelial Story Is Getting Its Day
21:34 • 2min
Is There Anything That Fructos Can Do Better Than Glucos?
23:13 • 2min
Is It Possible to Replete Your Liver Glicogen Faster?
25:02 • 2min
Is Maternal Hyperglycemia a Cause of Metabolic Disfunction?
26:52 • 2min
Is There an Epigenetic Disaster?
28:28 • 2min
Dopemin Receptors Go Down in Response to Constant Bombardment by Dopemine?
30:45 • 2min
Coke Is a Toxic Drug
32:23 • 2min
Drugs That Down Regulate Receptors
33:55 • 2min
Dopomin and Ethenal in the Brain?
35:31 • 2min
What's the Physiology of Withdrawal?
37:02 • 2min
Pet Atricx
38:41 • 2min
Is It the Added Sugar?
40:49 • 2min
What Is the Difference Between Store Bought and Real Food?
42:24 • 2min
Every Diet That Works Is Real Food
44:18 • 1min
Do You Have a Sensation of What It Costs?
45:44 • 2min
Iso Coloric Substitute of Frictosorglucosrictos
47:23 • 3min
Type 2 Diabetes - What's Going On?
50:14 • 2min
Glucose Absorption and Diarhea
52:02 • 2min
Denoval Hypogenesis
53:35 • 2min
Do You Believe That Insolent Resistance Is the Result of Metabalxindrum?
55:05 • 2min
Metabolxandrome
56:43 • 2min
Clinical Depression Increases Vistral Fat
58:19 • 2min
How to Measure Heart Rate Variability?
01:00:05 • 2min
Cortisal and Obesity
01:01:35 • 2min
Hepatic Lucos Output Increases Because of Insolen Resistant Hepatocytes
01:03:15 • 2min
Insolent Causes Inflammation and Cell Division
01:04:46 • 2min
Diabedes Control
01:06:32 • 2min
Are All Calories Equal?
01:08:14 • 2min
How Much Fibre Is in an Apple?
01:09:46 • 2min
What Are the Gut Bacteria Doing?
01:11:16 • 2min
What's Soluble Fibre?
01:12:52 • 2min
The Food System Needs to Change
01:14:26 • 2min
How Do You Change the Business Model?
01:16:31 • 2min
Would Food Get More Expensive if We Got Rid of All Food Subsidies?
01:18:11 • 2min
Is Theresereany Ab?
01:20:02 • 1min
The Forward Slash Podcast
01:21:31 • 2min
In this episode, Rob Lustig — a researcher, an expert in fructose metabolism, and a former pediatric endocrinologist — discusses what’s wrong with the current food environment, and what we can do to reduce our chances of becoming part of the obesity, diabetes, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD) epidemics. Rob recently earned a Master of Studies in Law because he believes that educating people about sugar from a scientific standpoint is only half the equation: the other half involves changing policy, which he explains in this episode.
We discuss:
- What’s the difference between glucose and fructose? [7:00];
- Do we have biomarkers that can give us some indication of average exposure to fructose over a given period of time? [14:20];
- What’s the difference between ALT and AST? [18:45];
- Inflammation, endothelial function, and uric acid [21:30];
- Is there something that fructose does better than glucose? [23:45];
- For children that undergo a remarkable shift from metabolic health to metabolic derangement, is there a concern that these kids suffer an epigenetic hit that makes it harder for them later in life? [26:15];
- How many times do you have to introduce a savory food vs a sugary food to an infant before they will accept it? [29:30];
- How are alcohol and fructose similar in how they affect the brain? [33:51];
- Advice for parents and kids for creating a sustainable environment that's going to prevent them from running into metabolic problems [40:30];
- Why do some populations have a higher risk for NAFLD? [45:42];
- What causes NAFLD? [48:45];
- Is insulin resistance the result of NAFLD or is NAFLD the result of insulin resistance? [56:00];
- HRV, cortisol, and norepinephrine [1:00:30];
- What are the actual mechanisms that links metabolic syndrome, insulin resistance, fatty liver, and type 2 diabetes? [1:03:00];
- Is the food industry still saying that all calories contribute equally to adiposity and insulin resistance? [1:09:00];
- What is the difference between soluble and insoluble fiber and why do you need both? [1:13:00];
- How can we change the food system when 10 companies control almost 90 percent of the Calories we consume in the US? [1:15:00]; and
- More.
Learn more at www.PeterAttiaMD.com