Commune with Jeff Krasno The Science of Metabolic Health with Dr. Ben Bikman
Nov 13, 2025
Join Dr. Ben Bikman, a metabolic research scientist and professor, as he dives into the intricate world of insulin and its critical influence on our health. He uncovers how insulin resistance contributes to weight gain, fatigue, and chronic diseases. Learn about the surprising connection between insulin resistance and fertility, plus insights into how diet and lifestyle changes—like intermittent fasting and resistance training—can restore metabolic health. Discover the role of ketones in brain health and the risks associated with diabetes medications.
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Insulin’s Central Role In Metabolism
- Insulin is an essential, anabolic hormone that affects every cell and promotes growth while inhibiting breakdown.
- Imbalances in insulin therefore ripple across organs, explaining insulin resistance's broad impact on health.
Three Root Causes Of Insulin Resistance
- Three primary causes of insulin resistance are stress (cortisol/epinephrine), inflammation, and chronically elevated insulin.
- Chronically high insulin is the most actionable cause because we can measure and directly lower it.
Hyperinsulinemia Creates Resistance
- Too much insulin itself drives insulin resistance via a biological principle: excess causes adaptive resistance.
- Frequent refined-carb meals keep insulin chronically elevated and sustain that vicious cycle.
