
Metabolic Freedom With Ben Azadi #1125 Stop Aging In Its Tracks! The Incredible Longevity Molecule You’ve Never Heard Of with Dr. Andrew Salzman
Oct 13, 2025
In this fascinating discussion, Dr. Andrew Salzman, a Harvard-trained physician and pioneering NAD+ researcher, reveals how NAD+ can combat aging and boost vitality. He explains the decline of NAD+ with age and its link to energy loss and inflammation. Listeners learn about practical methods to enhance NAD+ levels through ketogenic diets, fasting, and supplements. Dr. Salzman also emphasizes the role of gratitude in longevity, making this conversation a blend of science and inspiration for those seeking to age vibrantly.
AI Snips
Chapters
Books
Transcript
Episode notes
NAD Is Central To Cellular Aging
- NAD is a simple but critical coenzyme present in every cell that powers metabolism, immunity, and cognition.
- NAD levels decline from about age 20 and are roughly half by ages 50–60, driving many aging effects.
NAD Powers ATP And Longevity Enzymes
- NAD participates directly in mitochondria to produce ATP via the electron transport chain.
- NAD also enables enzymes like PARP and sirtuins that protect against aging beyond ATP production.
Use Ketosis To Preserve NAD
- Enter ketosis and fasting to spare NAD because ketone metabolism needs about one-fourth the NAD to make ATP compared with glucose.
- Use ketogenic strategies to increase NAD+ and shift NADH back to NAD+ via BHB.





