Nutrition Facts with Dr. Greger The Anti-Aging Pathways of AMPK (Part 2)
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Nov 28, 2024 Can a diabetes drug really help you live longer? The discussion dives into the potential anti-aging effects of metformin, revealing its role in managing blood sugar and cholesterol. Researchers are investigating its life-extension properties and side effects. Alongside medication, the emphasis shifts to lifestyle changes that can prevent diabetes, showcasing a study where nutrition eliminated diabetes risk. Listeners are encouraged to share their health success stories and learn about transformative health resources.
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Metformin's Herbal Origin Story
- Metformin originated from an herbal remedy in the Middle Ages, derived from a toxic plant called goat's rue.
- The toxic compound was modified into a safe, effective diabetes drug that activates AMPK to lower blood sugar.
Metformin's AMPK Energy Shift
- Metformin activates AMPK, which shifts the body from growth to preservation mode, reducing blood sugar, cholesterol, fat, and fibrosis.
- This energy-conserving shift may also slow cancer progression by limiting energy available for tumor growth.
Metformin's Lifespan Effects Vary
- Metformin extends lifespan in worms and improves healthspan in mice via AMPK activation.
- Rats resistant to calorie restriction showed no lifespan benefit, suggesting metformin's effects depend on the AMPK pathway.
