The Ultimate Human with Gary Brecka

214. Methylation Test Explained: Stop Guessing What Supplements You Need

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Oct 30, 2025
Leila Sertel, the CEO of OptimallyMe and an expert in at-home genetic methylation testing, joins the conversation. She discusses the importance of methylation in nutrient conversion and its connection to various health conditions like anxiety and autoimmune diseases. Leila also demonstrates the use of the new UK methylation test kit, emphasizing how targeted supplementation can correct deficiencies. The duo explores how chronic stress affects immunity and the significant role of sleep in brain health, making for an engaging and informative dialogue.
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ADVICE

Get A Methylation Test Once

  • Do a genetic methylation test once in your lifetime to stop guessing supplements.
  • Gary Brecka says the test reveals lifelong deficiencies so supplementation becomes targeted.
INSIGHT

Methylation Is Your Biochemical Refinery

  • Methylation is the biochemical refinery that converts nutrients into usable forms.
  • Gary Brecka compares it to refining crude oil into gasoline for the body to use.
INSIGHT

Methylation Shapes Neurotransmitters

  • Faulty methylation can impair neurotransmitter synthesis and drive mood, addiction, and focus problems.
  • Gary links impaired conversion of tryptophan and tyrosine to serotonin and dopamine issues.
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