LONGEVITY with Nathalie Niddam #398: The Dopamine Biohack | Brain Chemistry, Motivation & Testosterone Secrets Revealed With Lucas Aoun
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Dec 23, 2025 
Lucas Aoun, a renowned Australian naturopath and biohacker, shares his journey from pharmacy to supplement formulation. He discusses the importance of dopamine in enhancing motivation and productivity, introducing the concept of 'cosmetic neurology.' Lucas reveals innovative nootropics like theacrine and uridine's role in dopamine boosts, along with insights on alcohol alternatives like kava. He also highlights the significance of testosterone and thyroid health in men's wellness, and discusses dietary diversity's impact on performance.
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Dopamine As A Task-Tuned Lever
- Dopamine drives motivation and productivity and can be purposefully tuned for different tasks.
- Lucas Aoun calls this approach "cosmetic neurology": shape neurotransmitter profiles to fit the task.
Stacking Uridine And Omega‑3s
- Try uridine plus high-dose EPA/DHA to increase dopamine release and D2 receptor expression.
- Use L-phenylalanine (250–500 mg sublingual) for a social-energy boost without disrupting sleep.
Effort‑Linked Dopamine Is Healthy
- Dopamine released without effort (passive rewards) is the core problem with modern tech.
- Reward should follow effort to reinforce useful behavior and prevent hijacking by convenience.