

Healthy Aging with NAD+
36 snips Aug 14, 2025
Explore the vital role of NAD+ in cellular health and how it influences aging. Discover how NAD+ levels decline over time and the implications for metabolism. The conversation dives into the potential of NAD+ boosters to extend lifespan and enhance healthspan. You'll learn about the pros and cons of nicotinic acid as a supplement, backed by historical trials and emerging research that challenges common misconceptions.
AI Snips
Chapters
Books
Transcript
Episode notes
NAD+ Is Central To Metabolism And Cell Health
- NAD+ is an essential cofactor required for about 500 enzymes and critical metabolic energy extraction.
- The body constantly synthesizes, recycles, and breaks down NAD+ to maintain cellular vitality.
NAD+ Decline With Age Is Not Universal
- Popular claims that NAD+ universally declines with age are not well supported by the limited and inconsistent evidence.
- Some tissues show modest declines, others show none, so the universal-decline premise is misleading.
Rodent Benefits Don’t Guarantee Human Results
- In rodents, NAD+ boosters produced dramatic multi-system benefits and sometimes lifespan extension.
- These effects in animals fuel excitement but may not predict human outcomes.